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December 1979, Vol 133, No. 12 >
Article | December 1979

Further Evaluation of the Optimum Age for Rubella Vaccine Administration FREE

Jeanette Wilkins, MD; Paul F. Wehrle, MD
[+] Author Affiliations

Reprint requests to General Research Laboratory Bldg, Room 2G-24, Los Angeles County-University of Southern California Medical Center, 1129 N State St, Los Angeles, CA 90033 (Dr Wilkins).


Am J Dis Child. 1979;133(12):1237-1239. doi:10.1001/archpedi.1979.02130120029004.
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• The hemagglutination-inhibition (HI) antibody responses of 452 children to HPV-77,DE5 rubella vaccine were studied. Results indicated that seroconversion rates and geometric mean titers in infants inoculated at 12 through 14 months of age are comparable with those achieved in older children. "Vaccine failures" seem to occur randomly in vaccinees after 1 year of age; the infectivity of individual vaccines is questioned. The persistence of HI antibody was evaluated through serial sampling up to three years postinoculation.

(Am J Dis Child 133:1237-1239, 1979)

REFERENCES

1 +
Krugman S, Giles JP, Friedman H, et al:  Studies on immunity to measles . J Pediatr 66:471-488, 1965;.
2 +
Wilkins J, Wehrle PF, Portnoy B:  Live, further-attenuated rubeola vaccine: Serologic responses among term and low birth weight infants . Am J Dis Child 123:190-192, 1972;.
3 +
 Report of the Committee on Infectious Diseases , in American Academy of Pediatrics, 1977 Redbook , ed 18. Evanston, Ill, 1977;, table 1, p 3.
4 +
 Measles vaccine . Public Health Service Advisory Committee on Immunization Practices. Morbidity Mortality Weekly Rep 25:359, 1976;.
5 +
Wilkins J, Wehrle PF:  Evidence for reinstatement of infants 12 through 14 months of age into routine measles immunization programs . Am J Dis Child 132:164-166, 1978;.
6 +
Palmer DF, Herrmann KL, Lincoln RE, et al (eds): A Procedural Guide to the Performance of the Standardized Rubella Hemagglutination-Inhibition Test . Center for Disease Control Immunology Series, No. 2, Atlanta, 1970;.
7 +
Wilkins J, Leedom JM, Portnoy B, et al:  Reinfection with rubella virus despite live vaccine induced immunity: Trials of HPV-77 and HPV-80 live rubella virus vaccines and subsequent artificial and natural challenge studies . Am J Dis Child 118:275-294, 1969;.
8 +
Balfour HH, Amren DP:  Rubella, measles and mumps antibodies following vaccination of children: A potential rubella problem . Am J Dis Child 132:573-577, 1978;.
9 +
Goldblum N, Swartz TA, Klingberg W, et al:  Immunization with live attenuated rubella virus vaccine (HPV-77): Clinical and serological results in children and adolescents in Israel . Am J Dis Child 118:190-196, 1969;.
10 +
Wilkins J, Leedom JM, Portnoy B, et al:  Epidemiological implications of rubella "vaccine failures." Am J Dis Child 123:31-33, 1972;.
11 +
Schiff GM, Donath R, Rotte T:  Experimental rubella studies: I. Clinical and laboratory features of infection caused by the Brown strain rubella virus. II. Artificial challenge studies of adult vaccinees . Am J Dis Child 118:269-274, 1969;.
12 +
Davis WJ, Larson HE, Simsarian JP, et al:  A study of rubella immunity and resistance to reinfection . JAMA 215:600-608, 1971;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Krugman S, Giles JP, Friedman H, et al:  Studies on immunity to measles . J Pediatr 66:471-488, 1965;.
2 +
Wilkins J, Wehrle PF, Portnoy B:  Live, further-attenuated rubeola vaccine: Serologic responses among term and low birth weight infants . Am J Dis Child 123:190-192, 1972;.
3 +
 Report of the Committee on Infectious Diseases , in American Academy of Pediatrics, 1977 Redbook , ed 18. Evanston, Ill, 1977;, table 1, p 3.
4 +
 Measles vaccine . Public Health Service Advisory Committee on Immunization Practices. Morbidity Mortality Weekly Rep 25:359, 1976;.
5 +
Wilkins J, Wehrle PF:  Evidence for reinstatement of infants 12 through 14 months of age into routine measles immunization programs . Am J Dis Child 132:164-166, 1978;.
6 +
Palmer DF, Herrmann KL, Lincoln RE, et al (eds): A Procedural Guide to the Performance of the Standardized Rubella Hemagglutination-Inhibition Test . Center for Disease Control Immunology Series, No. 2, Atlanta, 1970;.
7 +
Wilkins J, Leedom JM, Portnoy B, et al:  Reinfection with rubella virus despite live vaccine induced immunity: Trials of HPV-77 and HPV-80 live rubella virus vaccines and subsequent artificial and natural challenge studies . Am J Dis Child 118:275-294, 1969;.
8 +
Balfour HH, Amren DP:  Rubella, measles and mumps antibodies following vaccination of children: A potential rubella problem . Am J Dis Child 132:573-577, 1978;.
9 +
Goldblum N, Swartz TA, Klingberg W, et al:  Immunization with live attenuated rubella virus vaccine (HPV-77): Clinical and serological results in children and adolescents in Israel . Am J Dis Child 118:190-196, 1969;.
10 +
Wilkins J, Leedom JM, Portnoy B, et al:  Epidemiological implications of rubella "vaccine failures." Am J Dis Child 123:31-33, 1972;.
11 +
Schiff GM, Donath R, Rotte T:  Experimental rubella studies: I. Clinical and laboratory features of infection caused by the Brown strain rubella virus. II. Artificial challenge studies of adult vaccinees . Am J Dis Child 118:269-274, 1969;.
12 +
Davis WJ, Larson HE, Simsarian JP, et al:  A study of rubella immunity and resistance to reinfection . JAMA 215:600-608, 1971;.

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