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November 1979, Vol 133, No. 11 >
Article | November 1979

Rubella Vaccination FREE

STEPHEN R. PREBLUD, MD; PHILLIP I. NIEBURG, MD; A. DAVID BRANDLING-BENNETT, MD; ALAN R. HINMAN, MD; KENNETH L. HERRMANN, MD
Am J Dis Child. 1979;133(11):1202. doi:10.1001/archpedi.1979.02130110110026.
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Sir.—We wish to comment on the recent article in the Journal by Balfour and Amren (132:573-577, 1978) and the subsequent commentary by Dudgeon (132:748-750, 1978) regarding rubella vaccine-induced immunity. The rubella geometric mean titers (GMTs) of seropositive persons reported by Balfour and Amren are lower than those usually seen in vaccine recipients.1.2 This fact plus the unusually high rate of seronegativity, which they acknowledge, suggest that the antibody assay system they used was relatively insensitive. Were the results obtained when the sera were sent to Cincinnati similar to those obtained locally in incidence of seronegativity and in GMT?

We agree with Balfour and Amren that "the critical issue is whether the seronegative girls are truly susceptible to rubella." We do not believe, however, that "the only way" to find out is to challenge them with wild rubella virus. Instead, we agree with the suggestion made previously by these

REFERENCES

1 +
Weibel RE, Buynak EB, McLean AA, et al:  Persistence of antibody after administration of monovalent and combined live attenuated measles, mumps, and rubella virus vaccines . Pediatrics 61:5-11, 1978;.
2 +
Herrmann KL, Halstead SB, BrandlingBennett AD, et al:  Rubella immunization: Persistence of antibody four years after a large-scale field trial . JAMA 235:2201-2204, 1976;.
3 +
Balfour HH, Amren DP:  Rubella vaccine (HPV-77 DE5Shai) fails to sustain antibody titers . Lancet 2:1130-1131, 1977;.
4 +
MacDonald H, Tobin JO'H, Cradock-Watson JE, et al:  Antibody titers in women six to eight years after the administration of RA27/3 and Cendehill rubella vaccines . J Hyg 80:337-347, 1978;.
5 +
Just M, Berger-Hernandez R, Bürgin-Wolff A:  Serum antibodies nine years after Cendehill rubella immunization . Lancet 2:1349-1350, 1977;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Weibel RE, Buynak EB, McLean AA, et al:  Persistence of antibody after administration of monovalent and combined live attenuated measles, mumps, and rubella virus vaccines . Pediatrics 61:5-11, 1978;.
2 +
Herrmann KL, Halstead SB, BrandlingBennett AD, et al:  Rubella immunization: Persistence of antibody four years after a large-scale field trial . JAMA 235:2201-2204, 1976;.
3 +
Balfour HH, Amren DP:  Rubella vaccine (HPV-77 DE5Shai) fails to sustain antibody titers . Lancet 2:1130-1131, 1977;.
4 +
MacDonald H, Tobin JO'H, Cradock-Watson JE, et al:  Antibody titers in women six to eight years after the administration of RA27/3 and Cendehill rubella vaccines . J Hyg 80:337-347, 1978;.
5 +
Just M, Berger-Hernandez R, Bürgin-Wolff A:  Serum antibodies nine years after Cendehill rubella immunization . Lancet 2:1349-1350, 1977;.

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