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October 1979, Vol 133, No. 10 >
Article | October 1979

Pancreatitis and Reye's Syndrome FREE

Gregory H. Ellis, MD; L. David Mirkin, MD; Mark C. Mills, MD
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Am J Dis Child. 1979;133(10):1014-1016. doi:10.1001/archpedi.1979.02130100038007.
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• A review of 18 cases of Reye's syndrome autopsied at Indiana University Hospital since 1970 was done to document pancreatic lesions associated with the syndrome. A spectrum of inflammatory lesions was identified and grouped into four categories: group 1, no changes; group 2, minimal microscopic changes; group 3, moderate changes, ie, focal necrosis, exudates, or congestion; and group 4, severe acute pancreatitis. Patients in group 4 often had clinical or laboratory data suggesting the onset of pancreatitis after hospitalization. Acute pancreatitis is associated with Reye's syndrome, and patients should be monitored for its development. Hypotension, hypocalcemia, and glucose lability may herald the onset of acute pancreatitis in these patients.

(Am J Dis Child 133:1014-1016, 1979)

REFERENCES

1 +
Blumenthal HT, Probstein JG:  Acute pancreatitis in the newborn, in infancy, and childhood . Am Surg 27:533-539, 1961;.
2 +
Stover SL, Wanglee P, Kennedy C:  Acute hemorrhagic pancreatitis and other visceral changes associated with acute encephalopathy . J Pediatr 73:235-241, 1968;.
3 +
Morens DM, Hammar SL, Heicher DA:  Idiopathic acute pancreatitis in children. Association with a clinical picture resembling Reye syndrome . Am J Dis Child 128:401-404, 1974;.
4 +
Gilboa N:  Idiopathic acute pancreatitis in children . Am J Dis Child 129:984, 1975;.
5 +
Morens DM:  Idiopathic acute pancreatitis in children . Am J Dis Child 129:984-985, 1975;.
6 +
US Dept of Health, Education, and Welfare, Public Health Service:  Outbreaks of Reye syndrome: Utah, Arizona, Colorado . Mortal Morbid Weekly Rep 28:39, 40, 45, 1979;.
7 +
Huttenlocher PR:  Reye's syndrome: Relation of outcome to therapy . J Pediatr 80:845-850, 1972;.
8 +
Pross DC, Bradford WD, Krueger RP:  Reye's syndrome treated with peritoneal dialysis . Pediatrics 45:845-847, 1970;.
9 +
Snodgrass PS: Harrison's Principles of Internal Medicine . New York, McGraw-Hill Book Co Inc, 1977;, pp 1636-1637.
10 +
Carone FA, Liebow AA:  Acute pancreatic lesions in patients treated with ACTH and adrenal corticoids . N Engl J Med 257:690-697, 1957;.
11 +
Laraya-Cuasay LR, Wolfe R, Hughes WT:  Acute pancreatitis and hypoglycemia . Clin Pediatr 525:528, 1968;.
12 +
Zollinger RM, Keith LM Jr, Ellison EH:  Pancreatitis . N Engl J Med 251:497-502, 1954;.
13 +
Rothenmich NO, von Haam E:  Pancreatic encephalopathy . J Clin Endocrinol 1:872-881, 1941;.
14 +
Glick TH, Likosky WH, Levitt LP, et al:  Reye's syndrome: An epidemiologic approach . Pediatrics 46:371-377, 1970;.
15 +
Reye RDK, Morgan G, Baral J:  Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood . Lancet 2:749-752, 1963;.
16 +
Bourgeois CH, Olson L, Comer D, et al:  Encephalopathy and fatty degeneration of the viscera . Am J Clin Pathol 56:558-571, 1971;.
17 +
Glasgow AM, Cotton RB, Bourgeois CH, et al:  Reye's syndrome: II. Occurrence in the absence of severe fatty infiltration of the liver . Am J Dis Child 124:834-836, 1972;.
18 +
Buntain WL, Wood JB, Wolley MM:  Pancreatitis in childhood . J Pediatr Surg 13:143-149, 1978;.

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References

1 +
Blumenthal HT, Probstein JG:  Acute pancreatitis in the newborn, in infancy, and childhood . Am Surg 27:533-539, 1961;.
2 +
Stover SL, Wanglee P, Kennedy C:  Acute hemorrhagic pancreatitis and other visceral changes associated with acute encephalopathy . J Pediatr 73:235-241, 1968;.
3 +
Morens DM, Hammar SL, Heicher DA:  Idiopathic acute pancreatitis in children. Association with a clinical picture resembling Reye syndrome . Am J Dis Child 128:401-404, 1974;.
4 +
Gilboa N:  Idiopathic acute pancreatitis in children . Am J Dis Child 129:984, 1975;.
5 +
Morens DM:  Idiopathic acute pancreatitis in children . Am J Dis Child 129:984-985, 1975;.
6 +
US Dept of Health, Education, and Welfare, Public Health Service:  Outbreaks of Reye syndrome: Utah, Arizona, Colorado . Mortal Morbid Weekly Rep 28:39, 40, 45, 1979;.
7 +
Huttenlocher PR:  Reye's syndrome: Relation of outcome to therapy . J Pediatr 80:845-850, 1972;.
8 +
Pross DC, Bradford WD, Krueger RP:  Reye's syndrome treated with peritoneal dialysis . Pediatrics 45:845-847, 1970;.
9 +
Snodgrass PS: Harrison's Principles of Internal Medicine . New York, McGraw-Hill Book Co Inc, 1977;, pp 1636-1637.
10 +
Carone FA, Liebow AA:  Acute pancreatic lesions in patients treated with ACTH and adrenal corticoids . N Engl J Med 257:690-697, 1957;.
11 +
Laraya-Cuasay LR, Wolfe R, Hughes WT:  Acute pancreatitis and hypoglycemia . Clin Pediatr 525:528, 1968;.
12 +
Zollinger RM, Keith LM Jr, Ellison EH:  Pancreatitis . N Engl J Med 251:497-502, 1954;.
13 +
Rothenmich NO, von Haam E:  Pancreatic encephalopathy . J Clin Endocrinol 1:872-881, 1941;.
14 +
Glick TH, Likosky WH, Levitt LP, et al:  Reye's syndrome: An epidemiologic approach . Pediatrics 46:371-377, 1970;.
15 +
Reye RDK, Morgan G, Baral J:  Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood . Lancet 2:749-752, 1963;.
16 +
Bourgeois CH, Olson L, Comer D, et al:  Encephalopathy and fatty degeneration of the viscera . Am J Clin Pathol 56:558-571, 1971;.
17 +
Glasgow AM, Cotton RB, Bourgeois CH, et al:  Reye's syndrome: II. Occurrence in the absence of severe fatty infiltration of the liver . Am J Dis Child 124:834-836, 1972;.
18 +
Buntain WL, Wood JB, Wolley MM:  Pancreatitis in childhood . J Pediatr Surg 13:143-149, 1978;.

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