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August 1979, Vol 133, No. 8 >
Article | August 1979

Juvenile Chronic Myelogenous Leukemia and Dermal Histiocytosis:  In Von Recklinghausen's Disease FREE

Marc Bestak, MD; Denis R. Miller, MD; Janet S. Mouradian, MD
[+] Author Affiliations

Reprint requests to Department of Pediatric Hematology/Oncology, New York Hospital-Cornell Medical Center, 525 E 68th St, New York. NY 10021 (Dr Bestak).


Am J Dis Child. 1979;133(8):831-833. doi:10.1001/archpedi.1979.02130080071014.
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• A 4-year-old boy with multiple café-au-lait spots and a family history of neurofibromatosis had generalized edema, histiocytic rash characterized by benign histiocytic infiltration, hepatomegaly, and life-threatening infection. Six months later, progressive splenomegaly led to juvenile chronic myelocytic leukemia that eventually proved fatal. The case represents an important association of diseases.

(Am J Dis Child 133:831-833, 1979)

REFERENCES

1 +
Lascari A: General Aspects in Leukemia in Childhood . Springfield, Ill, Charles C Thomas Publisher, 1973;, p 13.
2 +
Reich SD, Wiernik PH:  Von Recklinghausen neurofibromatosis and acute leukemia . Am J Dis Child 130:888-889, 1976;.
3 +
McEvoy MW, Mann JR:  Neurofibromatosis with leukemia . Br Med J 3:641, 1971;.
4 +
McWhirter WR, Savage DCL, Williams BM:  Neurofibromatosis with leukemia . Br Med J 4:114-115, 1971;.
5 +
Hardisty R, Spud D, Till M:  Granulocytic leukemia in childhood . Br J Haematol 10:551-556, 1964;.
6 +
Fraumeni JF, Manning MD, Mitus WJ:  Acute childhood leukemia: Epidemiologic study by cell type of 1,263 cases at the Children's Cancer Research Foundation in Boston , 1947-1965;. J Natl Cancer Inst 46:461-470, 1971.
7 +
Fraumeni JF Jr:  Neurofibromatosis and childhood leukemia . Br Med J 4:489-490, 1971;.
8 +
Bader JZ, Miller RW:  Neurofibromatosis and childhood leukemia . J Pediatr 92:925-929, 1978;.
9 +
Cockington RA:  Leukemic infiltration of the gastrointestinal tract: An unusual case of protein-losing enteropathy . Med J Aust 1:103-105, 1975;.
10 +
Smith KL, Johnson W:  Classification of chronic myelocytic leukemia in children . Cancer 34:670-679, 1974;.
11 +
Mauer AM, Lampkin BC, McWilliams MB:  The leukemias and reticuloendothelioses , in Nathan DG, Oski FA (eds): Hematology of Infancy and Childhood . Philadelphia, WB Saunder Co, 1973;, p 700.
12 +
Fienman N, Yakovac WC:  Neurofibromatosis in childhood . J Pediatr 76:339-346, 1970;.
13 +
Riccardi VM, Kleiner B:  Neurofibromatosis: A neoplastic birth defect with two age peaks of severe problems . Birth Defects 13:131-138, 1977;.
14 +
Walker-Smith JA, Skyring AP, Mistilis SP:  Use of "Cr Cl3 in the diagnosis of protein-losing enteropathy . Gut 8:166-168, 1967;.
15 +
Colon AR, Sandberg DH:  Protein-losing enteropathy in children . South Med J 66:641-644, 1973;.
16 +
Miller DR:  Raised fetal hemoglobin in childhood leukemia . Br J Haemat 17:103-112, 1969;.
17 +
Vogel JM, Vogel P:  Idiopathic histiocytosis: A discussion of eosinophilic granuloma, the Hand-Schüller-Christian syndrome, and the Letterer-Siwe syndrome . Semin Hematol 9:349-369, 1972;.
18 +
Lucaya J:  Histiocytosis X . Am J Dis Child 121:289-295, 1971;.
19 +
Cederbaum SD, Niwayama G, Stiehm ER, et al:  Combined immunodeficiency presenting as the Letterer-Siwe syndrome . J Pediatr 85:466-471, 1974;.
20 +
Gotoff SP, Esterly NB:  Histiocytosis . J Pediatr 85:592-593, 1974;.
21 +
Scott RB, Robb-Smith AJT:  Histiocytic medullary reticulosis . Lancet 2:194-198, 1939;.
22 +
Nelson P, Santamaria A, Olson RL, et al:  Generalized lymphohistiocytic infiltration . Pediatrics 27:931-950, 1961;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Lascari A: General Aspects in Leukemia in Childhood . Springfield, Ill, Charles C Thomas Publisher, 1973;, p 13.
2 +
Reich SD, Wiernik PH:  Von Recklinghausen neurofibromatosis and acute leukemia . Am J Dis Child 130:888-889, 1976;.
3 +
McEvoy MW, Mann JR:  Neurofibromatosis with leukemia . Br Med J 3:641, 1971;.
4 +
McWhirter WR, Savage DCL, Williams BM:  Neurofibromatosis with leukemia . Br Med J 4:114-115, 1971;.
5 +
Hardisty R, Spud D, Till M:  Granulocytic leukemia in childhood . Br J Haematol 10:551-556, 1964;.
6 +
Fraumeni JF, Manning MD, Mitus WJ:  Acute childhood leukemia: Epidemiologic study by cell type of 1,263 cases at the Children's Cancer Research Foundation in Boston , 1947-1965;. J Natl Cancer Inst 46:461-470, 1971.
7 +
Fraumeni JF Jr:  Neurofibromatosis and childhood leukemia . Br Med J 4:489-490, 1971;.
8 +
Bader JZ, Miller RW:  Neurofibromatosis and childhood leukemia . J Pediatr 92:925-929, 1978;.
9 +
Cockington RA:  Leukemic infiltration of the gastrointestinal tract: An unusual case of protein-losing enteropathy . Med J Aust 1:103-105, 1975;.
10 +
Smith KL, Johnson W:  Classification of chronic myelocytic leukemia in children . Cancer 34:670-679, 1974;.
11 +
Mauer AM, Lampkin BC, McWilliams MB:  The leukemias and reticuloendothelioses , in Nathan DG, Oski FA (eds): Hematology of Infancy and Childhood . Philadelphia, WB Saunder Co, 1973;, p 700.
12 +
Fienman N, Yakovac WC:  Neurofibromatosis in childhood . J Pediatr 76:339-346, 1970;.
13 +
Riccardi VM, Kleiner B:  Neurofibromatosis: A neoplastic birth defect with two age peaks of severe problems . Birth Defects 13:131-138, 1977;.
14 +
Walker-Smith JA, Skyring AP, Mistilis SP:  Use of "Cr Cl3 in the diagnosis of protein-losing enteropathy . Gut 8:166-168, 1967;.
15 +
Colon AR, Sandberg DH:  Protein-losing enteropathy in children . South Med J 66:641-644, 1973;.
16 +
Miller DR:  Raised fetal hemoglobin in childhood leukemia . Br J Haemat 17:103-112, 1969;.
17 +
Vogel JM, Vogel P:  Idiopathic histiocytosis: A discussion of eosinophilic granuloma, the Hand-Schüller-Christian syndrome, and the Letterer-Siwe syndrome . Semin Hematol 9:349-369, 1972;.
18 +
Lucaya J:  Histiocytosis X . Am J Dis Child 121:289-295, 1971;.
19 +
Cederbaum SD, Niwayama G, Stiehm ER, et al:  Combined immunodeficiency presenting as the Letterer-Siwe syndrome . J Pediatr 85:466-471, 1974;.
20 +
Gotoff SP, Esterly NB:  Histiocytosis . J Pediatr 85:592-593, 1974;.
21 +
Scott RB, Robb-Smith AJT:  Histiocytic medullary reticulosis . Lancet 2:194-198, 1939;.
22 +
Nelson P, Santamaria A, Olson RL, et al:  Generalized lymphohistiocytic infiltration . Pediatrics 27:931-950, 1961;.

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