Epidemic Occurrence of Neonatal Necrotizing Enterocolitis FREE

Mary Guinan, MD, PhD; Dennis Schaberg, MD; Frederic W. Bruhn, MD; C. Joan Richardson, MD; William W. Fox, MD

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Reprint requests to Hospital Infections Branch, CDC, 1600 Clifton Rd, Atlanta 30333 (Dr Guinan).

Am J Dis Child. 1979;133(6):594-597. doi:10.1001/archpedi.1979.02130060034005.

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ABSTRACT

ABSTRACT | REFERENCES

• In case-control studies of three epidemics of neonatal necrotizing enterocolitis (NEC) in three different high-risk nurseries in three states, no particular risk factor was associated with affected infants or their mothers. Epidemic cases had higher birth weights and Apgar scores and fewer perinatal difficulties than those previously reported for sporadic cases. Seven infants fed primarily breast milk were not protected against disease. Early antibiotic therapy was associated with a significantly decreased risk of disease in one outbreak. In two hospitals, affected infants who received antibiotic therapy during the first three days of life had a significantly later disease onset. The occurrence of the disease in epidemics and the decreased risk or modification of disease with antibiotic therapy support an infectious etiology for NEC.

(Am J Dis Child 133:594-597, 1979)

REFERENCES

ABSTRACT | REFERENCES

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Bhargava SK, Mittal SK, Saxena HMK, et al: An outbreak of necrotizing enterocolitis in a special care newborn nursery . Indian Pediatr 10:551-553, 1973;.

Virnig NL, Reynolds JW: Epidemiologic aspects of neonatal necrotizing enterocolitis . Am J Dis Child 128:186-190, 1974;.

Desai NS, Cunningham MD, Wilson HD: Nosocomial epidemics of neonatal necrotizing enterocolitis . Pediatr Res 9:296, 1975;.

Barlow B, Santulli T, Heird WC, et al: An experimental study of acute neonatal enterocolitis: The importance of breast milk . J Pediatr Surg 9:587-595, 1974;.

Egan EA, Bonzalo M, Nelson RM, et al: A prospective controlled trial of oral kanamycin in the prevention of neonatal necrotizing enterocolitis . J Pediatr 89:467-470, 1976;.

Hill HR, Hunt CD, Matsen JM: Nosocomial colonization with Klebsiella, type 26, in a neonatal intensive care unit associated with an outbreak of sepsis, meningitis, and necrotizing enterocolitis . J Pediatr 85:415-419, 1974;.

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