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Adrenal Hemorrhage in a Newborn With Beckwith-Wiedemann Syndrome

Am J Dis Child. 1978;132(11):1142-1143. doi:10.1001/archpedi.1978.02120360098022.
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Two patients with Beckwith-Wiedemann syndrome have recently been reported1 with adrenal calcifications that were presumed to be a consequence of unrecognized adrenal hemorrhage. We describe a patient with Beckwith-Wiedemann syndrome in the neonatal period with a massive hemorrhage of the right adrenal gland. To our knowledge, no other cases of confirmed bleeding into the adrenals have been reported in patients with this syndrome.

Report of a Case.—A male infant born after normal labor, with a birth weight of 3.7 kg, was transferred to the University of Pavia (Italy) Pediatric Department on the first day of life because of intense cyanosis, tachypnea, and macroglossia. On admission, an umbilical hernia, ear lobe anomaly, and hemihypertrophy were noted. The liver was palpable 3 cm below the right costal margin, and two round masses, thought to be enlarged kidneys, were palpable in each flank. A grade 3/6 systolic murmur was present. Laboratory


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