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November 1978, Vol 132, No. 11 >
Article | November 1978

Recurrent Reye's Syndrome FREE

Michael E. Pichichero, MD; Edward R. B. McCabe, MD, PhD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, Strong Memorial Hospital, 601 Elmwood Ave, Rochester, NY 14642 (Dr Pichichero).


Am J Dis Child. 1978;132(11):1097-1099. doi:10.1001/archpedi.1978.02120360053009.
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References
Comments

• The clinical diagnosis of recurrent Reye's syndrome can be made only after a systemic exclusion of other diagnostic possibilities. We report such a case, providing guidelines for a complete clinical and biochemical evaluation of this entity. If a comprehensive study of patients experiencing recurrent Reye's syndrome is to be made, each patient must be subjected to thorough examination.

(Am J Dis Child 132:1097-1099, 1978)

REFERENCES

1 +
Reye RDK, Morgan G, Baral J:  Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood . Lancet 2:749-752, 1963;.
2 +
Huttenlocker PR, Schwartz AD, Klatskin G:  Reye's syndrome: Ammonia intoxication as a possible factor in the encephalopathy . Pediatrics 43:443-454, 1969;.
3 +
Hilty MD, Romische CA, Delamater PV:  Reye's syndrome and hyperaminoacidemia . J Pediatr 84:363-365, 1974;.
4 +
Trauner D, Sweetman K, Holm J, et al:  Biochemical correlates of illness and recovery in Reye's syndrome . Ann Neurol 2:238-241, 1977;.
5 +
Tanaka K, Kean EA, Johnson B:  Jamaican vomiting sickness: Biochemical investigation of two cases . N Engl J Med 295:461-467, 1976;.
6 +
Chalmers RA, Lawson AM, Whitelaw A, et al:  Organic acids in Reye's like syndrome: Similarities with Jamaican vomiting sickness . Lancet 1:1156-1157, 1977;.
7 +
Roe CR, Schonberger LR, Gebach SH, et al:  Enzymatic alterations in Reye's syndrome: Prognostic implications . Pediatrics 55:119-126, 1975;.
8 +
Van Caillie M, Moun CL, Roy CL, et al:  Reye's syndrome: Relapses and neurological sequelae . Pediatrics 59:244-249, 1977;.
9 +
Partin JC, Partin JS, Schubert WK:  Fatty liver in Reye's syndrome: Is it a distinct morphologic entity?  abstracted. Gastroenterology 65:563, 1973;.
10 +
Thaler MM, Hoogenraad NJ, Boswell M:  Reye's syndrome due to a novel protein-tolerant variant of ornithine transcarbamylase deficiency . Lancet 2:438-440, 1974;.
11 +
Karpati G, Carpenter S, Engel A, et al:  The syndrome of systemic carnitine deficiency . Neurology 25:16-24, 1975;.
12 +
Glasgow A, Eng G, Engel A:  Systemic carnitine deficiency: A cause of recurrent "Reye's syndrome." Pediatr Res 12:552, 1978;.
13 +
Parker D, DiMauro S, Shinner J, et al:  Deficiency of muscle carnitine presenting as Reye's encephalopathy in a male infant . Pediatr Res 10:451, 1976;.
14 +
Goodman SI, Norenberg MD, Shikes RH, et al:  Glutaric aciduria: Biochemical and morphologic considerations . J Pediatr 90:746-750, 1977;.
15 +
Lovejoy FH Jr, Smith AL, Bresnan MJ, et al:  Clinical staging in Reye syndrome . Am J Dis Child 128:36-41, 1974;.
16 +
Aoki Y, Lombroso CT:  Prognostic value of electroencephalography in Reye's syndrome . Neurology 23:333-343, 1973;.
17 +
Goldstein AS, Hoogenraad NJ, Johnson JD, et al:  Metabolic and genetic studies in a family with ornithine transcarbamylase deficiency . Pediatr Res 8:5-12, 1974;.
18 +
Goodman SI, Hammond KG:  The detection of pathological organic aciduria , in Dorfman A (ed): Antenatal Diagnosis . Chicago, University of Chicago Press, 1972;, pp 127-135.
19 +
Corey L, Rubin RJ, Bregman D, et al:  Diagnostic criteria for influenza B-associated Reye's syndrome: Clinical vs. pathologic criteria . Pediatrics 60:702-708, 1977;.
20 +
Corey L, Rubin RJ, Hattwick MAW:  Reye's syndrome: Clinical progression and evaluation of therapy . Pediatrics 60:708-714, 1977;.
21 +
Glasgow AM, Cotton RB, Dhiensiri K:  Reye's syndrome: I. Blood ammonia and consideration of the nonhistologic diagnosis . Am J Dis Child 124:827-833, 1972;.
22 +
Samaha EF, Glau E, Berardinelli JL:  Reye's syndrome: Clinical diagnosis and treatment with peritoneal dialysis . Pediatrics 53:336-340, 1974;.
23 +
Lovejoy FH, Bresnan MJ, Lombroso CT, et al:  Anticerebral edema therapy in Reye's syndrome . Arch Dis Child 50:933-937, 1975;.
24 +
Partin JC, Schubert WK, Partin JS:  Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera) . N Engl J Med 285:1339-1343, 1971;.
25 +
Snodgrass PJ, DeLong GR:  Urea-cycle enzyme deficiencies and an increased nitrogen load producing hyperammonemia in Reye's syndrome . N Engl J Med 294:855-860, 1976;.
26 +
Brown T, Hug G, Lansky L, et al:  Transiently reduced activity of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of children with Reye's syndrome . N Engl J Med 294:861-867, 1976;.
27 +
Croker JFS:  Insecticide and viral interaction as a cause of fatty visceral changes and encephalopathy in the mouse . Lancet 2:22-24, 1974;.
28 +
Aprille JR:  Reye's syndrome: Patient serum alters mitochondrial function and morphology in vitro . Science 197:908-910, 1977;.
29 +
Sinatra F, Yoshida T, Applebaum M, et al:  Abnormalities of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of patients with Reye's syndrome . Pediatr Res 9:829-833, 1975;.
30 +
Shih VE, Efron ML:  Urea cycle disorders , in Stansbury JB, Wyngaarden JB, Fredrickson DS (eds): Metabolic Basis of Inherited Disease . New York, McGraw-Hill Book Co Inc, 1972;, pp 370-392.
31 +
Scriver C, Rosenberg L: Amino Acid Metabolism and Its Disorders . Philadelphia, WB Saunders Co, 1973;, pp 239-242.

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References

1 +
Reye RDK, Morgan G, Baral J:  Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood . Lancet 2:749-752, 1963;.
2 +
Huttenlocker PR, Schwartz AD, Klatskin G:  Reye's syndrome: Ammonia intoxication as a possible factor in the encephalopathy . Pediatrics 43:443-454, 1969;.
3 +
Hilty MD, Romische CA, Delamater PV:  Reye's syndrome and hyperaminoacidemia . J Pediatr 84:363-365, 1974;.
4 +
Trauner D, Sweetman K, Holm J, et al:  Biochemical correlates of illness and recovery in Reye's syndrome . Ann Neurol 2:238-241, 1977;.
5 +
Tanaka K, Kean EA, Johnson B:  Jamaican vomiting sickness: Biochemical investigation of two cases . N Engl J Med 295:461-467, 1976;.
6 +
Chalmers RA, Lawson AM, Whitelaw A, et al:  Organic acids in Reye's like syndrome: Similarities with Jamaican vomiting sickness . Lancet 1:1156-1157, 1977;.
7 +
Roe CR, Schonberger LR, Gebach SH, et al:  Enzymatic alterations in Reye's syndrome: Prognostic implications . Pediatrics 55:119-126, 1975;.
8 +
Van Caillie M, Moun CL, Roy CL, et al:  Reye's syndrome: Relapses and neurological sequelae . Pediatrics 59:244-249, 1977;.
9 +
Partin JC, Partin JS, Schubert WK:  Fatty liver in Reye's syndrome: Is it a distinct morphologic entity?  abstracted. Gastroenterology 65:563, 1973;.
10 +
Thaler MM, Hoogenraad NJ, Boswell M:  Reye's syndrome due to a novel protein-tolerant variant of ornithine transcarbamylase deficiency . Lancet 2:438-440, 1974;.
11 +
Karpati G, Carpenter S, Engel A, et al:  The syndrome of systemic carnitine deficiency . Neurology 25:16-24, 1975;.
12 +
Glasgow A, Eng G, Engel A:  Systemic carnitine deficiency: A cause of recurrent "Reye's syndrome." Pediatr Res 12:552, 1978;.
13 +
Parker D, DiMauro S, Shinner J, et al:  Deficiency of muscle carnitine presenting as Reye's encephalopathy in a male infant . Pediatr Res 10:451, 1976;.
14 +
Goodman SI, Norenberg MD, Shikes RH, et al:  Glutaric aciduria: Biochemical and morphologic considerations . J Pediatr 90:746-750, 1977;.
15 +
Lovejoy FH Jr, Smith AL, Bresnan MJ, et al:  Clinical staging in Reye syndrome . Am J Dis Child 128:36-41, 1974;.
16 +
Aoki Y, Lombroso CT:  Prognostic value of electroencephalography in Reye's syndrome . Neurology 23:333-343, 1973;.
17 +
Goldstein AS, Hoogenraad NJ, Johnson JD, et al:  Metabolic and genetic studies in a family with ornithine transcarbamylase deficiency . Pediatr Res 8:5-12, 1974;.
18 +
Goodman SI, Hammond KG:  The detection of pathological organic aciduria , in Dorfman A (ed): Antenatal Diagnosis . Chicago, University of Chicago Press, 1972;, pp 127-135.
19 +
Corey L, Rubin RJ, Bregman D, et al:  Diagnostic criteria for influenza B-associated Reye's syndrome: Clinical vs. pathologic criteria . Pediatrics 60:702-708, 1977;.
20 +
Corey L, Rubin RJ, Hattwick MAW:  Reye's syndrome: Clinical progression and evaluation of therapy . Pediatrics 60:708-714, 1977;.
21 +
Glasgow AM, Cotton RB, Dhiensiri K:  Reye's syndrome: I. Blood ammonia and consideration of the nonhistologic diagnosis . Am J Dis Child 124:827-833, 1972;.
22 +
Samaha EF, Glau E, Berardinelli JL:  Reye's syndrome: Clinical diagnosis and treatment with peritoneal dialysis . Pediatrics 53:336-340, 1974;.
23 +
Lovejoy FH, Bresnan MJ, Lombroso CT, et al:  Anticerebral edema therapy in Reye's syndrome . Arch Dis Child 50:933-937, 1975;.
24 +
Partin JC, Schubert WK, Partin JS:  Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera) . N Engl J Med 285:1339-1343, 1971;.
25 +
Snodgrass PJ, DeLong GR:  Urea-cycle enzyme deficiencies and an increased nitrogen load producing hyperammonemia in Reye's syndrome . N Engl J Med 294:855-860, 1976;.
26 +
Brown T, Hug G, Lansky L, et al:  Transiently reduced activity of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of children with Reye's syndrome . N Engl J Med 294:861-867, 1976;.
27 +
Croker JFS:  Insecticide and viral interaction as a cause of fatty visceral changes and encephalopathy in the mouse . Lancet 2:22-24, 1974;.
28 +
Aprille JR:  Reye's syndrome: Patient serum alters mitochondrial function and morphology in vitro . Science 197:908-910, 1977;.
29 +
Sinatra F, Yoshida T, Applebaum M, et al:  Abnormalities of carbamyl phosphate synthetase and ornithine transcarbamylase in liver of patients with Reye's syndrome . Pediatr Res 9:829-833, 1975;.
30 +
Shih VE, Efron ML:  Urea cycle disorders , in Stansbury JB, Wyngaarden JB, Fredrickson DS (eds): Metabolic Basis of Inherited Disease . New York, McGraw-Hill Book Co Inc, 1972;, pp 370-392.
31 +
Scriver C, Rosenberg L: Amino Acid Metabolism and Its Disorders . Philadelphia, WB Saunders Co, 1973;, pp 239-242.

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