We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Picture of the Month

Sydney S. Gellis, MD; Murray Feingold, MD; Juan F. Sotos, MD; Carolyn A. Romshe, MD; Edward A. Cutler, DO
Am J Dis Child. 1978;132(10):1033-1034. doi:10.1001/archpedi.1978.02120350097020.
Text Size: A A A
Published online


Denouement and Discussion 

Kocher-Debré-Semelaigne Syndrome 

Manifestations  Kocher1 first reported the association of generalized muscular "hypertrophy" and hypothyroidism; Debré and Semelaigne2 subsequently noted the decrease in muscle size after thyroid therapy. Because of generalized muscle enlargement, especially of the calf muscles, patients with this syndrome usually have an athletic appearance.3 The cause of the large muscles is not known and histopathological findings are not consistent.4Other conditions in which muscles may appear enlarged are certain types of muscular dystrophy, hypertrophia muscularum vera, de Lange's extrapyramidal syndrome of muscular hypertrophy, familial periodic paralysis, lipodystrophy, and myotonia congenita. Large muscles are occasionally found in children with primary hypothyroidism and therefore it may be difficult to determine if these patients should be classified as having Kocher-Debré-Semelaigne syndrome, especially since the pathogenesis of the muscle enlargement is not known.

Genetics  An autosomal recessive mode of inheritance has been suggested.

Treatment  After treatment with levo-thyroxine decrease


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.