Primary Intimal Fibroplasia in a Child With Down's Syndrome FREE

Gary R. Fleisher, MD; Billy E. Buck, MD; David Cornfeld, MD

Reprint requests to Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104 (Dr Fleisher).

Am J Dis Child. 1978;132(7):700-703. doi:10.1001/archpedi.1978.02120320060014.

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

• A 14-year-old girl known to have trisomy 21 and who came to us with weight loss followed by hypertension proved to have diffuse arterial dysplasia involving the intimal layer (primary intimal fibroplasia). This is a rare cause of elevated blood pressure in children and has not been previously reported in a child with Down's syndrome. Unusual features of this case also include the widespread distribution of the lesions limited to the large muscular distributing arteries, the rapidly progressive course, and the predominance of abdominal signs and symptoms.

(Am J Dis Child 132:700-703, 1978)

REFERENCES

ABSTRACT | REFERENCES

Loggie JMH: Hypertension in children and adolescents: I. Causes and diagnostic studies . J Pediatr 74:331-355, 1969;.

Vyden JK, Nagasawa K, Corday E.: Hemodynamic consequences of acute occlusion of the superior mesenteric artery . Am J Cardiol 34:687-691, 1974;.

Sinclair RA, Antonovych TT, Mostofi FK: Renal proliferative arteriopathies and associated glomerular changes . Hum Pathol 7:565-588, 1976;.

Heptinstall RH (ed): Pathology of the Kidney . Boston, Little Brown & Co, 1974;, pp 163-221.

Fager DB, Bigler JA, Simonds JP: Polyarteritis nodosa in infancy and childhood . J Pediatr 39:65-79, 1951;.

Wagenvoort CA, Harris LE, Brown AL, et al: Giant-cell arteritis with aneurysm formation in children . Pediatrics 32:861-867, 1963;.

Lee K, Sohn K, Hong C, et al: Primary arteritis (pusleless disease) in Korean children . Acta Paediatr Scand 56:526-532, 1967;.

McCormack LJ, Hazard JB, Poutasse EF: Obstructive lesions of the renal artery associated with remediable hypertension . Am J Pathol 34:582, 1958;.

Palubinskas AJ, Wylie EJ: Roentgen diagnosis of fibromuscular hyperplasia of the renal arteries . Radiology 76:634-639, 1961;.

Hunt JC, Harrison EG, Kincaid OW: Idiopathic fibrous and fibromuscular stenoses at the renal arteries associated with hypertension . Proc Staff Meet Mayo Clin 37:181-216, 1962;.

Kincaid OW, David GD, Hallerman FJ, et al: Fibromuscular dysplasia of the renal arteries . Am J Roentgenol 104:271-282, 1968;.

McCormack LJ, Poutasse EF, Meaney TF, et al: A pathologic-arteriographic correlation of renal arterial disease . Am Heart J 72:188-198, 1966;.

Harrison EG, McCormack LJ: Pathologic classification of renal arterial disease in renovascular hypertension . Mayo Clin Proc 46:161-167, 1971;.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal