Article |

Nebulized Racemic Epinephrine by IPPB for the Treatment of Croup:  A Double-Blind Study

C. Ross Westley, MD; Ernest K. Cotton, MD; John G. Brooks, MD
Am J Dis Child. 1978;132(5):484-487. doi:10.1001/archpedi.1978.02120300044008.
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• Racemic epinephrine has been advocated for the treatment of croup, but controlled studies have not proved it more effective than saline. Twenty patients (aged 4 months to 5 years) hospitalized with acute croup and persistent inspiratory stridor at rest were randomly assigned to one of two treatment groups: saline or racemic epinephrine, both nebulized and delivered by intermittent positive pressure breathing. Clinical scores were significantly improved (P <.01) at ten and 30 minutes following the treatment with racemic epinephrine but not at 120 minutes. Racemic epinephrine was significantly more effective than saline at 10 (P <.01) and 30 minutes (P <.05) but not at 120 minutes after the treatment. We conclude that nebulized racemic epinephrine is effective treatment for the acute signs of croup.

(Am J Dis Child 132:484-487, 1978)


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