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Changing Perspectives on Acetaminophen

Am J Dis Child. 1978;132(5):459-460. doi:10.1001/archpedi.1978.02120300019001.
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In this issue of the Journal (p 466), Wilson and his colleagues report a fatality as a result of acetaminophen overdose, compounded as it was by simultaneous phenobarbital ingestion and phenacetin treatment. The issues addressed highlight lessons for each of us who deal either with accidental or with purposeful poisonings. In addition to emphasizing the toxic potential of acetaminophen, the report stresses the potentiating effect of other drugs on the toxic process. At the same time, it serves to document the therapeutic implications of our understanding of the pharmacokinetics involved. Viewing the current scene against the past may serve to clarify the importance of their observations.

Paralleling the Poison Control Movement of the 50s and 60s were numerous reports documenting the severe effects of aspirin overdoses. Whether the result of an "accidental" ingestion by a toddler ("purposeful" in his or her eyes), an inadvertently prescribed, excessive dosage regimen, or a


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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