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'Cure' in Chronic Fungal Disease

WILLIAM G. WINTER JR, MD
Am J Dis Child. 1978;132(4):432. doi:10.1001/archpedi.1978.02120290104027.
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Sir.—Let me react to the article by Hayden et al in the Journal (131:927, 1977). We would point out that our case to which they kindly refer in their third reference also had "apparent remission," but recurred thereafter. I believe strongly that the word "cure" is usually inappropriate in chronic fungal disease and certainly so if only short-term follow-up is available. For Hayden et al, as for us, intraarticular amphotericin B was "something to do." I doubt very much that it was substantially better than the policy of no action whatsoever. I would refer the interested reader to our article on coccidioidal arthritis1 for yet another look at how imperfect is our treatment of chronic fungal disease by amphotericin B, whether by the topical or intravenous route.

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