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March 1978, Vol 132, No. 3 >
Article | March 1978

Intercurrent Infection in Lead Poisoning FREE

HENRIETTA K. SACHS, MD
Am J Dis Child. 1978;132(3):315-316. doi:10.1001/archpedi.1978.02120280099021.
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Recurrence of plumbism due to mobilization of stored lead has been an unquestioned concept.1 Demineralization of bone is thought to occur when acidosis is induced by fever, causing an increase in circulating lead. Even patients who have been treated with chelating agents are believed at risk during intercurrent infection until residual soft tissue lead is transferred to bone and ceases, after a year, to be available.2-4

In 29 children with normal lead values studied by Oleske, examination of trace metals in response to acute infection revealed a rise in copper and fall in zinc, but no change in blood lead concentration.5 The possibility that blood lead does not rise during infection even in children who were lead poisoned was suggested during a current study of 104 patients recalled for evaluation whose maximum blood lead concentration two to ten years earlier ranged from 100 to 471 μg.

REFERENCES

1 +
Aub JC, Fairhall L, Minot A, et al: Lead Poisoning, Medicine Monographs , Baltimore, Williams & Wilkins Co, vol 7, 1926;.
2 +
Ford FR: Diseases of the Nervous System , ed 6. Springfield, Ill, Charles C Thomas Publisher, 1973;.
3 +
Barnett HL: Pediatrics , ed 15. New York, Appleton-Century-Crofts Inc, 1972;.
4 +
Harrison's Principles of Internal Medicine , ed 7. New York, McGraw-Hill, 1974;.
5 +
Oleske JM, Valentine JL, Minnefor AB:  The effects of acute infection on blood lead, copper and zinc levels in children . Health Lab Sci 12:230, 1975;.
6 +
Sachs HK, Blanksma LA, Murray EF, et al:  Ambulatory treatment of lead poisoning: Report of 1,155 cases . Pediatrics 46:389, 1970;.

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References

1 +
Aub JC, Fairhall L, Minot A, et al: Lead Poisoning, Medicine Monographs , Baltimore, Williams & Wilkins Co, vol 7, 1926;.
2 +
Ford FR: Diseases of the Nervous System , ed 6. Springfield, Ill, Charles C Thomas Publisher, 1973;.
3 +
Barnett HL: Pediatrics , ed 15. New York, Appleton-Century-Crofts Inc, 1972;.
4 +
Harrison's Principles of Internal Medicine , ed 7. New York, McGraw-Hill, 1974;.
5 +
Oleske JM, Valentine JL, Minnefor AB:  The effects of acute infection on blood lead, copper and zinc levels in children . Health Lab Sci 12:230, 1975;.
6 +
Sachs HK, Blanksma LA, Murray EF, et al:  Ambulatory treatment of lead poisoning: Report of 1,155 cases . Pediatrics 46:389, 1970;.

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