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February 1978, Vol 132, No. 2 >
Article | February 1978

A Fatal Case of Peliosis of the Liver and Spleen FREE

DENIS R. BENJAMIN, BSc, MB, BCh; BELINDA SHUNK, MD
Am J Dis Child. 1978;132(2):207-208. doi:10.1001/archpedi.1978.02120270105023.
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The condition of diffuse angiomatoid change in the liver known as peliosis hepatis is uncommon, with only eight cases reported in infancy and childhood.1 While the etiology remains obscure, anabolic steroids have recently been implicated in certain instances.2-4 We report a further and most unusual case, in a child with aplastic anemia treated with oxymetholone, in which the peliotic process involved both the liver and spleen. Death was due to the rupture of a peliotic lesion on the surface of the spleen. Of additional interest was the presence of chronic persistent hepatitis demonstrated to be due to hepatitis B antigen.

Report of a Case.—This male patient developed idiopathic aplastic anemia at the age of 9 years (June 1970). His initial corticosteroid therapy (prednisone 10 to 60 mg/day) was supplemented with oxymetholone (25 to 100 mg/day) and he received a total of 80 grams over the next five-years.

REFERENCES

1 +
Nuernberger SP, Ramos CV:  Peliosis hepatis in an infant . J Pediatr 87:424-426, 1975;.
Link to Article
2 +
Naeim F, Cooper PH, Semion AA:  Peliosis hepatis, possible etiologic role of anabolic steroids . Arch Pathol 95:284-285, 1973;.
3 +
Groos G, Arnold OM, Brittenger G:  Peliosis hepatis after long term administration of oxymetholone . Lancet 1:874, 1974;.
Link to Article
4 +
Bernstein MS, Hunger RL, Yachuin S:  Hepatoma and peliosis hepatis developing in a patient with Fanconi's syndrome . N Engl J Med 284:1135-1136, 1971;.
Link to Article
5 +
Hamilton FT, Lubitz JM:  Peliosis hepatis: Report of three cases with discussion of pathogenesis . Arch Pathol 54:564-572, 1952;.
6 +
Bergs VV, Scotti TM:  Virus induced peliosis hepatis in rats . Science 158:377-378, 1967;.
Link to Article
7 +
Gordon BS, Wolf J, Kranse T, et al:  Peliosis hepatis and cholestasis following administration of norethandrolone . Am J Clin Pathol 33:156-165, 1960;.
8 +
Yanoff M, Rawson AJ:  Peliosis hepatis: An anatomic study with demonstration of two varieties . Arch Pathol 77:159-165, 1964;.

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References

1 +
Nuernberger SP, Ramos CV:  Peliosis hepatis in an infant . J Pediatr 87:424-426, 1975;.
Link to Article
2 +
Naeim F, Cooper PH, Semion AA:  Peliosis hepatis, possible etiologic role of anabolic steroids . Arch Pathol 95:284-285, 1973;.
3 +
Groos G, Arnold OM, Brittenger G:  Peliosis hepatis after long term administration of oxymetholone . Lancet 1:874, 1974;.
Link to Article
4 +
Bernstein MS, Hunger RL, Yachuin S:  Hepatoma and peliosis hepatis developing in a patient with Fanconi's syndrome . N Engl J Med 284:1135-1136, 1971;.
Link to Article
5 +
Hamilton FT, Lubitz JM:  Peliosis hepatis: Report of three cases with discussion of pathogenesis . Arch Pathol 54:564-572, 1952;.
6 +
Bergs VV, Scotti TM:  Virus induced peliosis hepatis in rats . Science 158:377-378, 1967;.
Link to Article
7 +
Gordon BS, Wolf J, Kranse T, et al:  Peliosis hepatis and cholestasis following administration of norethandrolone . Am J Clin Pathol 33:156-165, 1960;.
8 +
Yanoff M, Rawson AJ:  Peliosis hepatis: An anatomic study with demonstration of two varieties . Arch Pathol 77:159-165, 1964;.

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