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February 1978, Vol 132, No. 2 >
Article | February 1978

Monocyte Functional Capacity in Chronic Neutropenia FREE

Martha F. Greenwood, MD; Erwin A. Jones, MD; Phillip Holland, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, University of Kentucky Medical Center, Lexington, KY 40506 (Dr Greenwood).


Am J Dis Child. 1978;132(2):131-135. doi:10.1001/archpedi.1978.02120270029005.
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References
Comments

• The bactericidal activity of monocytes from a child with chronic benign granulocytopenia who has had virtual absence of neutrophils yet minimal infections since birth was examined against Escherichia coli and Staphylococcus aureus and compared with that of monocyte and neutrophils from 20 control subjects. Studies of monocyte function in this patient with no neutrophils revealed normal monocyte kill of both organisms when compared with control monocytes. Monocyte and neutrophil killing of both organisms was similar in control subjects at bacteria to phagocyte ratios of 1:1. When ratios of 3:1 were employed, however, control neutrophils were more effective than control and patient monocytes in reducing the number of viable organisms. These findings support the neutrophil as the more effective blood phagocyte but stress the importance of monocyte functional capacity in patients compromised by granulocytopenia or neutrophil functional defects.

(Am J Dis Child 132:131-135, 1978)

REFERENCES

1 +
Klebanoff SJ:  Iodination of bacteria: A bactericidal mechanism . J Exp Med 126:1063-1078, 1967;.
2 +
Klebanoff SJ:  Myeloperoxidase-halide-hydrogen peroxide anti-bacterial system . J Bact 95:2131-2138, 1968;.
3 +
Quie PG:  Bactericidal function of human polymorphonuclear leukocytes . Pediatrics 50:264-270, 1972;.
4 +
Douglas SD:  Disorders of neutrophil and monocyte function . Br J Haematol 21:493-496, 1971;.
5 +
Cline MJ, Lehrer RI:  Phagocytosis by human monocytes . Blood 32:423-435, 1968;.
6 +
Baehner RL, Johnston RB Jr:  Monocyte function in children with neutropenia and chronic infections . Blood 40:31-41, 1972;.
7 +
Steigbigel RT, Lambert LH Jr, Remington JS:  Phagocytic and bactericidal properties of normal human monocytes . J Clin Invest 53:131-142, 1974;.
8 +
Biggar WD, Holmes B, Page AR, et al:  Metabolic and functional studies of monocytes in congenital neutropenia . Br J Haematol 28:233-243, 1974;.
9 +
Twomey JJ, Douglass CC, Sharkey O Jr:  The monocytopenia of aplastic anemia . Blood 41:187-195, 1973;.
10 +
Rebuck JW, Crowley JH:  A method of studying leukocytic functions in vivo . Ann NY Acad Sci 59:757-805, 1955;.
11 +
Pearson HA:  Diseases of the blood: Development of the hematopoietic system , in Nelson WE (ed): Textbook of Pediatrics . Philadelphia, WB Saunders Co, 1969;, p 1043.
12 +
Boyum A:  Isolation of mononuclear cells and granulocytes from human blood . Scand J Clin Lab Invest 21( (suppl 97) ):77-89, 1968;.
13 +
Quie PG, White JG, Holmes B, et al:  In vitro bactericidal capacity of human polymorphonuclear leukocytes: Diminished activity in chronic granulomatous disease of childhood . J Clin Invest 46:668-679, 1967;.
14 +
Holland P, Holland NH, Cohn ZA:  The selective inhibition of macrophage phagocytic receptors by anti-membrane antibodies . J Exp Med 135:458-475, 1972;.
15 +
Rodey GE, Park BH, Windhorst DB, et al:  Defective bactericidal activity of monocytes in fatal granulomatous disease . Blood 33:813-820, 1969;.
16 +
Davis WC, Huber H, Douglas SD, Fudenberg HH:  A defect in circulating mononuclear phagocytes in chronic granulomatous disease of childhood . J Immunol 101:1093-1095, 1968;.
17 +
Root RK, Rosenthal AS, Balestra DJ:  Abnormal bactericidal, metabolic and lysosomal functions of Chediak-Higashi syndrome leukocytes . J Clin Invest 51:649-665, 1972;.
18 +
Drutz DJ, Cline MJ:  Intermittent neutrophil-monocyte bactericidal defects in a patient with sarcoidosis . Am Rev Resp Dis 112:387-392, 1975;.
19 +
Cline MJ:  Defective mononuclear phagocyte function in patients with myelomonocytic leukemia and in some patients with lymphoma . J Clin Invest 52:2185-2190, 1973;.

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References

1 +
Klebanoff SJ:  Iodination of bacteria: A bactericidal mechanism . J Exp Med 126:1063-1078, 1967;.
2 +
Klebanoff SJ:  Myeloperoxidase-halide-hydrogen peroxide anti-bacterial system . J Bact 95:2131-2138, 1968;.
3 +
Quie PG:  Bactericidal function of human polymorphonuclear leukocytes . Pediatrics 50:264-270, 1972;.
4 +
Douglas SD:  Disorders of neutrophil and monocyte function . Br J Haematol 21:493-496, 1971;.
5 +
Cline MJ, Lehrer RI:  Phagocytosis by human monocytes . Blood 32:423-435, 1968;.
6 +
Baehner RL, Johnston RB Jr:  Monocyte function in children with neutropenia and chronic infections . Blood 40:31-41, 1972;.
7 +
Steigbigel RT, Lambert LH Jr, Remington JS:  Phagocytic and bactericidal properties of normal human monocytes . J Clin Invest 53:131-142, 1974;.
8 +
Biggar WD, Holmes B, Page AR, et al:  Metabolic and functional studies of monocytes in congenital neutropenia . Br J Haematol 28:233-243, 1974;.
9 +
Twomey JJ, Douglass CC, Sharkey O Jr:  The monocytopenia of aplastic anemia . Blood 41:187-195, 1973;.
10 +
Rebuck JW, Crowley JH:  A method of studying leukocytic functions in vivo . Ann NY Acad Sci 59:757-805, 1955;.
11 +
Pearson HA:  Diseases of the blood: Development of the hematopoietic system , in Nelson WE (ed): Textbook of Pediatrics . Philadelphia, WB Saunders Co, 1969;, p 1043.
12 +
Boyum A:  Isolation of mononuclear cells and granulocytes from human blood . Scand J Clin Lab Invest 21( (suppl 97) ):77-89, 1968;.
13 +
Quie PG, White JG, Holmes B, et al:  In vitro bactericidal capacity of human polymorphonuclear leukocytes: Diminished activity in chronic granulomatous disease of childhood . J Clin Invest 46:668-679, 1967;.
14 +
Holland P, Holland NH, Cohn ZA:  The selective inhibition of macrophage phagocytic receptors by anti-membrane antibodies . J Exp Med 135:458-475, 1972;.
15 +
Rodey GE, Park BH, Windhorst DB, et al:  Defective bactericidal activity of monocytes in fatal granulomatous disease . Blood 33:813-820, 1969;.
16 +
Davis WC, Huber H, Douglas SD, Fudenberg HH:  A defect in circulating mononuclear phagocytes in chronic granulomatous disease of childhood . J Immunol 101:1093-1095, 1968;.
17 +
Root RK, Rosenthal AS, Balestra DJ:  Abnormal bactericidal, metabolic and lysosomal functions of Chediak-Higashi syndrome leukocytes . J Clin Invest 51:649-665, 1972;.
18 +
Drutz DJ, Cline MJ:  Intermittent neutrophil-monocyte bactericidal defects in a patient with sarcoidosis . Am Rev Resp Dis 112:387-392, 1975;.
19 +
Cline MJ:  Defective mononuclear phagocyte function in patients with myelomonocytic leukemia and in some patients with lymphoma . J Clin Invest 52:2185-2190, 1973;.

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