Twins, Conjoined Twins, and Cardiac Defects FREE

JACQUELINE A. NOONAN, MD

Am J Dis Child. 1978;132(1):17-18. doi:10.1001/archpedi.1978.02120260019001.

Text Size: A A A

Published online

Article

References

Comments

ABSTRACT

ABSTRACT | REFERENCES

Human twins have always been of special interest to pediatricians and others concerned with congenital malformations. Monozygous twins, which comprise 30% of all twins, arise from a single ovum and share identical genetic material, while dizygous twins arise from separate ova, each with a distinct genetic composition. A study of cardiac malformations in twins should provide some insight into the causation of congenital heart disease. Dr Ray Anderson¹ recently reviewed his experience in 109 sets of twins and triplets with a variety of cardiac defects. His study, which comprises the largest number of random cases so far published, revealed a concordance rate for cardiac defects of 8.2% in monozygous twins and 2.2% in dizygous twins. In an earlier but smaller study, I found similar results.² When I pooled the twin studies of Uchida and Rowe,³ Ross,⁴ and my own patients, a concordance rate of 8.8% was

REFERENCES

ABSTRACT | REFERENCES

Anderson RC: Congenital cardiac malformations in 109 sets of twins and triplets . Am J Cardiol 39:1045-1050, 1977;.
Link to Article

Noonan JA: Cardiovascular anomalies in twins (abstract) . Proc Soc Pediatr Res 54, 1963;.

Uchida IA, Rowe RD: Discordant heart anomalies in twins . Am J Hum Genet 9:133-140, 1957;.

Ross, LJ: Congenital cardiovascular anomalies in twins . Circulation 20:327-342, 1959;.
Link to Article

Bergsma D (ed): Conjoined Twins Birth Defects Original Article Series , New York, National Foundation-March of Dimes, vol 3, No. (1) , 1967;.

Hunter K: Duet for a Life-Time, The Story of the Original Siamese Twins . New York, CowardMcCann, Inc, 1964;.

Leachman RD, Latson JR, Kohler CM, et al: Cardiovascular evaluations of conjoined twins . Birth Defects 3:52-65, 1967;.

Tandom R, Sterns LP, Edwards JE: Thoracopagus twins, report of a case . Arch Pathol 98:248-251, 1974;.

Ivemark BI: Implications of agenesis of the spleen on the pathogenesis of cono-truncus anomalies in childhood . Acta Paediatr 44( (suppl 104) ):32-100, 1955;.
Link to Article

Nichols BL, Blattner RJ, Rudolph AJ: General clinical management of thoracopagus twins , in Bergsma D (ed): Conjoined Twins, Birth Defects Original Article Series . New York, National Foundation-March of Dimes, 1967;, vol 3, No. (1) , pp 38-51.

Gessner IH: Spectrum of congenital cardiac anomalies produced in chick embryos by mechanical interference with cardiogenesis . Circ Res 18:625-633, 1966;.
Link to Article

Gessner IH, Van Mierop LHS: Experimental production of cardiac defects: The spectrum of dextroposition of the aorta . Am J Cardiol 25:272-278, 1970;.
Link to Article

Rychter Z: Experimental morphology of the aortic arches and the heart loop in the chick embryos . Adv Morph 2:333-371, 1962;.

Hark JY, Paul MH, Gallen WJ, et al: Experimental production of hypoplastic left heart syndrome in the chick embryo . Am J Cardiol 31:51-56, 1973;.
Link to Article

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal