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December 1977, Vol 131, No. 12 >
Article | December 1977

HLA Antigens in Mucocutaneous Lymph Node Syndrome FREE

ICHIRO MATSUDA, MD; SHINZABRO HATTORI, MD; NORIYUKI NAGATA, MD; AKIO FRUSE, MD; HARUO NAMBU, MD; KATSUKI ITAKURA, MD; AKEMI WAKISAKA, MD
Am J Dis Child. 1977;131(12):1417-1418. doi:10.1001/archpedi.1977.02120250099033.
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Kawasaki disease or mucocutaneous lymph node syndrome (MLNS), first described by Kawasaki1-2 in 1974, is an acute febrile disease of unknown etiology. Until recently, more than 6,000 cases of this disease have been listed in the survey of a special study

group supported by the Japanese Ministry of Health and Welfare. Although a number of cases have been accumulated even outside of Japan,3-6 it is much less common elsewhere.

The etiology of the disease is now under investigation including the isolation of a Rickettsia-like body.7 There is a possibility that an immunopathological mechanism similar to that of juvenile rheumatoid arthritis and infantile polyarteritis nodosa is responsible, as evidenced by cardiac involvement, increased erythrocyte sedimentation rate, positive C-reactive protein and increased α2-globulin in serum.

Several immunopathological diseases are known to be associated with individual human lymphocytes antigen (HLA),8 but to date no investigation has been

REFERENCES

1 +
Kawasaki T, Kosaki F, Okawa S et al:  A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan . Pediatrics 54:271-276, 1974;.
2 +
 Kawasaki disease , editorial. Lancet 1:675-676, 1976;.
3 +
Brown JS, Billmeier GJ Jr, Cox F, et al:  Mucocutaneous lymph node syndrome in the continental United States . J Pediatr 88:81-83, 1976;.
4 +
John TJ, DeBenedetti CD, Zee ML:  Mucocutaneous lymph node syndrome in Arizona . Am J Dis Child 130:613-614, 1976;.
5 +
Valaes T:  Mucocutaneous lymph node drome drome (MLNS) in Athens, Greece . Pediatrics 55:295, 1975;.
6 +
Melish ME, Hicks RM, Larson EJ:  Mucocutaneous lymph node syndrome in the United States . Am J Dis Child 130:599-607, 1976;.
7 +
Hamashima Y, Kishi K, Tasaka K:  Rickett sia-like bodies in infantile acute febrile mucocutaneous lymph-node syndrome . Lancet 2:42, 1973;.
Link to Article
8 +
Svejgaard A, Platz P, Ryder LP, et al:  HL-A and disease associations—survey . Transplant Rev 22:3-43, 1975;.
9 +
Tominaga M, Ohshima K, Yanagawa Y, et al:  An epidemic analysis of family cases of mucocutaneous lymph-node syndrome . Pediatr Japan 18:59-63, 1977;.
10 +
Nakayama E, Itakura K, Yakura H, et al:  Sa 1, a possible new HL-A specificity found in the Japanese population . Vox Sang 27:134-140, 1974;.
Link to Article

Figures

Tables

Interactive Graphics

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Kawasaki T, Kosaki F, Okawa S et al:  A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan . Pediatrics 54:271-276, 1974;.
2 +
 Kawasaki disease , editorial. Lancet 1:675-676, 1976;.
3 +
Brown JS, Billmeier GJ Jr, Cox F, et al:  Mucocutaneous lymph node syndrome in the continental United States . J Pediatr 88:81-83, 1976;.
4 +
John TJ, DeBenedetti CD, Zee ML:  Mucocutaneous lymph node syndrome in Arizona . Am J Dis Child 130:613-614, 1976;.
5 +
Valaes T:  Mucocutaneous lymph node drome drome (MLNS) in Athens, Greece . Pediatrics 55:295, 1975;.
6 +
Melish ME, Hicks RM, Larson EJ:  Mucocutaneous lymph node syndrome in the United States . Am J Dis Child 130:599-607, 1976;.
7 +
Hamashima Y, Kishi K, Tasaka K:  Rickett sia-like bodies in infantile acute febrile mucocutaneous lymph-node syndrome . Lancet 2:42, 1973;.
Link to Article
8 +
Svejgaard A, Platz P, Ryder LP, et al:  HL-A and disease associations—survey . Transplant Rev 22:3-43, 1975;.
9 +
Tominaga M, Ohshima K, Yanagawa Y, et al:  An epidemic analysis of family cases of mucocutaneous lymph-node syndrome . Pediatr Japan 18:59-63, 1977;.
10 +
Nakayama E, Itakura K, Yakura H, et al:  Sa 1, a possible new HL-A specificity found in the Japanese population . Vox Sang 27:134-140, 1974;.
Link to Article

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