Article |

Teratogenicity of Anticonvulsive Medications

Am J Dis Child. 1977;131(12):1337-1339. doi:10.1001/archpedi.1977.02120250019001.
Text Size: A A A
Published online

The report by Feldman et al in this issue of the Journal (see p 1389) further indicts trimethadione, of the oxazolidinedione class of drugs, as one of the most potent teratogenic agents yet recognized in man. More than 80% of reported conceptuses exposed to trimethadione in utero have either been spontaneously aborted or malformed at birth. The phenotype has been similar in affected individuals and has been noted in the offspring of women who received trimethadione as the only anticonvulsant medication during pregnancy; hence the fetal trimethadione syndrome designation seems appropriate. The dysmorphic facies with a Mephistophelian upward slant to the eyebrows and the aberrant auricles appear to be the most consistent and unusual features along with mild to moderate growth deficiency. The most serious consequence is mental deficiency and the most frequent major malformations are cleft lip and/or cleft palate and cardiac defects.

The concern about the teratogenic impact


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.