Prodromal gastroenteritis seen in the hemolytic-uremic syndrome of childhood is infrequently cause of major problems in the treatment once acute renal failure is established and the diagnosis has been made.1-3 This communication describes a child in whom the development of spontaneous colonic perforation represented a severe, late gastrointestinal complication of the hemolytic-uremic syndrome.
Report of a Case.—A 4½-year-old girl was hospitalized with a one-week history of bloody diarrhea. The child had not urinated 30 hours prior to admission. She was a pale, lethargic, afebrile child, with a firm midline mass extending from the pubis to the umbilicus.
Admission laboratory data included the following values: hemoglobin concentration, 11 gm/100 ml; hematocrit reading, 29%; 1.5% reticulocytes; and 10,000 platelets per cubic millimeter. Peripheral blood smear revealed numerous burr cells and schistocytes. Examination of the bone marrow revealed normal cellularity. A prothrombin time was 13 seconds (control of 11 seconds). Blood