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Article |

Reliability of Salivary Theophylline as a Guide to Plasma Theophylline Levels

Stanley P. Galant, MD; Sherwin A. Gillman, MD; Leo H. Cummins, MD; Peter P. Kozak, MD; John J. Orcutt
Am J Dis Child. 1977;131(9):970-972. doi:10.1001/archpedi.1977.02120220036004.
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• Simultaneous saliva and plasma theophylline levels in 12 chronic asthmatic children were measured by high pressure liquid chromatography following administration of a theophylline preparation. In five subjects, simultaneous plasma and salivary theophylline were measured one week later. A strongly positive correlation between plasma and salivary theophylline levels was found at all time periods tested. There was no substantial difference in the plasma-saliva theophylline ratio determined one week later. A predicted plasma level was compared with the observed value. The proportionality of predicted to observed plasma theophylline levels using either the entire study group mean plasma-saliva ratio or each individual's ratio was approximately 1.00 with 9% variability. When a previously reported plasma-saliva theophylline ratio was used for comparison, the predicted plasma theophylline was 15% above the observed plasma level.

(Am J Dis Child 131:970-972, 1977)

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