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Arthritis Caused by Monosporium apiospermum Treated With Intra-articular Amphotericin B

Am J Dis Child. 1977;131(8):927. doi:10.1001/archpedi.1977.02120210105026.
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We describe a case of Maduromycosis in a child from Virginia who was seen with monarticular arthritis of the knee. A course of intra-articular administration of amphotericin B was followed by an apparent remission of this disease, which is rarely seen in the United States.1

Report of a Case.—A 6-year-old boy was admitted to North Carolina Memorial Hospital for evaluation of monarticular arthritis and fever. Nine months previously he had sustained a puncture wound with a dirty nail over the right patella without evidence of infection or joint involvement. One month earlier he had been hospitalized because of recurrent knee pain. At that time his temperature was 39.4 C. His right knee was warm and swollen with mild limitation of motion. There was point tenderness over the patella superior and lateral to the 5 mm scar of the prior nail puncture. Aspirated joint fluid contained 21,650 WBCs per


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