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Ampicillin-Resistant Haemophilus influenzae Meningitis Following an Ampicillin-Sensitive Bacteremia in an Infant

Am J Dis Child. 1977;131(7):812-813. doi:10.1001/archpedi.1977.02120200092022.
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Recent reports have described an increase in the incidence of Haemophilus influenzae infection.1.2 Ampicillin-resistant strains of H influenzae have recently been reported from many states.3 This is the report of a 6-month-old infant in whom, within a 28-day period, periorbital cellulitis and bacteremia followed by meningitis developed, both infections having been caused by H influenzae. The organism isolated from the first infection was sensitive to and the second resistant to ampicillin sodium.

Report of a Case.—A previously well 6-month-old male infant was admitted to Columbus Children's Hospital with left periorbital edema, erythema, and a temperature of 40 C. Blood culture yielded H influenzae type b, sensitive to both ampicillin sodium and chloramphenicol.

The infant was initially treated with ampicillin sodium (200 mg/kg/day) and methicillin sodium (200 mg/kg/day) administered intravenously for six days, at which time he was placed on a regimen of oral ampicillin (100 mg/kg/day),


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