Article |

Down Syndrome With Trisomy in One Triplet

Hiroshi Shiono, MD; Jun-Ichi Kadowaki; Hiromi Tsuneta; Bunsaku Nagai; Haruo Nanbu
Am J Dis Child. 1977;131(5):522-524. doi:10.1001/archpedi.1977.02120180036005.
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• The case presented here may be the first identified report of Down syndrome with 21 trisomy in one child of triplets. One triplet died at 1 month of age; his facial appearance was not typical of Down syndrome. Detailed testing of blood groups suggested identical origin in the remaining two children. However, the fluorescent banding technique of chromosome, one-way mixed lymphocyte culture test, and HLA typing were suggestive of dizygotic origin. Skin transplant studies supported this contention.

(Am J Dis Child 131:522-524, 1977)


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