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May 1977, Vol 131, No. 5 >
Article | May 1977

Down Syndrome With Trisomy in One Triplet FREE

Hiroshi Shiono, MD; Jun-Ichi Kadowaki; Hiromi Tsuneta; Bunsaku Nagai; Haruo Nanbu
[+] Author Affiliations

Reprint requests to Department of Legal Medicine, Sapporo Medical College, S1 W 17, Chuoku, Sapporo, Japan (Dr Shiono).


Am J Dis Child. 1977;131(5):522-524. doi:10.1001/archpedi.1977.02120180036005.
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• The case presented here may be the first identified report of Down syndrome with 21 trisomy in one child of triplets. One triplet died at 1 month of age; his facial appearance was not typical of Down syndrome. Detailed testing of blood groups suggested identical origin in the remaining two children. However, the fluorescent banding technique of chromosome, one-way mixed lymphocyte culture test, and HLA typing were suggestive of dizygotic origin. Skin transplant studies supported this contention.

(Am J Dis Child 131:522-524, 1977)

REFERENCES

1 +
Oster J:  Mongolism: A clinicogenealogical investigation comprising 526 mongols living on Seeland and Neighbouring island in Denmark . Opera Domo Biologiae Hereditariae Humanae 32:1-206, 1953;.
2 +
Allen G, Baroff GS:  Mongoloid twins and their siblings . Acta Genet 5:294-297, 1955;.
3 +
Keay AJ:  The significance of twins in mongolism in the light of new evidence . J Ment Defic Res 2:1-7, 1958;.
4 +
de Wolff PE, Scharer K, Lejeune J:  Contribution a l'étude des jumeaux mongoliens: Un cas de monozygotisme hétérocaryote . Helv Paediatr Acta 17:301-328, 1962;.
5 +
Zellweger H:  Familial aggregates of the 21-trisomy syndrome . Ann NY Acad Sci 155:784-792, 1968;.
6 +
Moorhead PS, Nowell PS, Mellman WJ, et al:  Chromosome preparations of leukocytes cultured from human peripheral blood . Exp Cell Res 20:613-616, 1960;.
7 +
Okajima M: Dermatoglyphic Studies on Twins . Tokyo, Sooseiji no Kenkyu, 1956;, pp 23-25.
8 +
Waardenburg PJ: Das menschliche Auge und seine Erbanlagen . The Hague, Nijhoff's Uitgevers-Mij, 1932;.
9 +
McDonald AD:  Mongolism in twins . J Med Genet 1:39-41, 1964;.
10 +
Jervis GA:  Mongolism in twins . Am J Ment Defic 47:364-369, 1943;.
11 +
Mackaye L:  Mongolism in nonindentical twins . Am J Dis Child 52:141-143, 1936;.
12 +
Gordon RG, Fraser-Roberts JA:  Paraplegia and mongolism in twins . Arch Dis Child 13:79-84, 1938;.
13 +
Nicholson DN, Keay AJ:  Mongolism in both twins of opposite sex . Arch Dis Child 32:325-327, 1959;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Oster J:  Mongolism: A clinicogenealogical investigation comprising 526 mongols living on Seeland and Neighbouring island in Denmark . Opera Domo Biologiae Hereditariae Humanae 32:1-206, 1953;.
2 +
Allen G, Baroff GS:  Mongoloid twins and their siblings . Acta Genet 5:294-297, 1955;.
3 +
Keay AJ:  The significance of twins in mongolism in the light of new evidence . J Ment Defic Res 2:1-7, 1958;.
4 +
de Wolff PE, Scharer K, Lejeune J:  Contribution a l'étude des jumeaux mongoliens: Un cas de monozygotisme hétérocaryote . Helv Paediatr Acta 17:301-328, 1962;.
5 +
Zellweger H:  Familial aggregates of the 21-trisomy syndrome . Ann NY Acad Sci 155:784-792, 1968;.
6 +
Moorhead PS, Nowell PS, Mellman WJ, et al:  Chromosome preparations of leukocytes cultured from human peripheral blood . Exp Cell Res 20:613-616, 1960;.
7 +
Okajima M: Dermatoglyphic Studies on Twins . Tokyo, Sooseiji no Kenkyu, 1956;, pp 23-25.
8 +
Waardenburg PJ: Das menschliche Auge und seine Erbanlagen . The Hague, Nijhoff's Uitgevers-Mij, 1932;.
9 +
McDonald AD:  Mongolism in twins . J Med Genet 1:39-41, 1964;.
10 +
Jervis GA:  Mongolism in twins . Am J Ment Defic 47:364-369, 1943;.
11 +
Mackaye L:  Mongolism in nonindentical twins . Am J Dis Child 52:141-143, 1936;.
12 +
Gordon RG, Fraser-Roberts JA:  Paraplegia and mongolism in twins . Arch Dis Child 13:79-84, 1938;.
13 +
Nicholson DN, Keay AJ:  Mongolism in both twins of opposite sex . Arch Dis Child 32:325-327, 1959;.

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