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Cholangiocarcinoma Associated With Biliary Cirrhosis Due to Congenital Biliary Atresia

Prakash B. Kulkarni, MB BS, DCH; Eugene C. Beatty Jr, MD
Am J Dis Child. 1977;131(4):442-444. doi:10.1001/archpedi.1977.02120170068013.
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• An 11-year-old girl developed cholangiocellular carcinoma in association with biliary cirrhosis due to congenital biliary atresia. An exploratory laparotomy and an operative cholangiogram at 3 months of age had confirmed the diagnosis of extra-hepatic biliary atresia. A liver biopsy specimen taken at 6 months of age showed biliary cirrhosis. The subsequent clinical course was characterized by persistent moderate jaundice, anemia, malnutrition, rickets, pathologic fractures, and recurrent gastrointestinal bleeding. The presence of cholangiocellular carcinoma of the liver with advanced biliary cirrhosis was established at an exploratory laparotomy a week before her death. We discuss here the pathogenesis of biliary cirrhosis and carcinoma of the liver; there may be a relation between the two in the childhood population.

(Am J Dis Child 131:442-444, 1977)

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