On Certain Physical-Chemical Properties of Infant Formulas FREE

W. E. SEGAR, MD; R. W. CHESNEY, MD

Am J Dis Child. 1977;131(2):137-138. doi:10.1001/archpedi.1977.02120150019001.

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ABSTRACT

ABSTRACT | REFERENCES

The article in this issue of the Journal by Paxson, Adcock, and Morriss (see p 139) directs the reader's attention to the variability in the osmolality of commonly used formulas. Further, it reminds us that notable differences in concentration exist either due to the variation among lots from a single manufacturer or due to alterations in the method of reconstitution. Formulas prepared by the use of a scoop may have an osmolality approaching twice that of the same formula reconstituted by weight per the manufacturer's formulation. Such differences in composition are certain to alter the response to the infant, particularly the low-birth-weight infant, to his feedings. Although the article by Paxson et al examines some formulas that would not ordinarily be used by physicians in the care of low-birth-weight infants, the consequences of using these formulas must be recognized.

The observation that formulas, especially those reconstituted through the use of

REFERENCES

ABSTRACT | REFERENCES

Colle E, Ayoub E, Raile R: Hypertonic dehydration (hypernatremia): The role of feedings high in solutes . Pediatrics 22:5-129, 1958;.

Franz MN, Segar WE: The association of various factors and hypernatremic diarrheal dehydration . Am J Dis Child 97:298-302, 1959;.

Finberg L: The possible role of the physician in causing hypernatremia in infants dehydrated from diarrhea . Pediatrics 22:2-5, 1958;.

Tomarelli RM: Osmolality, osmolarity, and renal solute load of infant formulas . J Pediatr 88:454-456, 1976;.

Day GM, Radde IC, Balfe JW, et al: Electrolyte abnormalities in very low birthweight infants . Pediatr Res 10:522, 1976;.

Book LS, Herbst JJ, Atherton SO, et al: Necrotizing enterocolitis in low-birth-weight infants fed an elemental formula . J Pediatr 87:602-605, 1975;.

Santulli TV, Schullinger JN, Heird WC, et al: Acute necrotizing enterocolitis in infancy: A review of 64 cases . Pediatrics 55:376-387, 1975;.

Frantz, ID III, L'Heureux P, Engel RR, et al: Necrotizing enterocolitis . J Pediatr 86:259-263, 1975;.

Kameda H, Abei T, Nasrallah S, et al: Functional and histological injury to intestinal mucosa produced by hypertonicity . Am J Physiol 214:1090-1095, 1968;.

Nashrallah SM, Coburn WM Jr, Iber FL: The effect of hypertonic mannitol on the intestine in man . Johns Hopkins Med J 123:134-137, 1968;.

Hunt JN, Pathak JD: Osmotic effects of some simple molecules and ions on gastric emptying . J Physiol 154:254-269, 1960;.

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