Oxolinic Acid Therapy for Urinary Tract Infections in Children FREE

Ronald M. Shapera, MD; John M. Matsen, MD

[+] Author Affiliations

Reprint requests to Department of Pathology, University of Utah Medical Center, Salt Lake City, UT 84132 (Dr Matsen).

Am J Dis Child. 1977;131(1):34-37. doi:10.1001/archpedi.1977.02120140036004.

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ABSTRACT

ABSTRACT | REFERENCES

• Thirty hospitalized children with Gram-negative bacillary urinary tract infections were treated with oxolinic acid for 14 to 21 days. Fifteen of 17 patients with uncomplicated and 11 of 13 with complicated urinary infections had favorable bacteriologic responses. Resistant organisms developed in four treatment failures. Oxolinic acid urine concentrations were well above the minimal inhibitory concentration for most strains of Escherichia coli, Klebsiella, Enterobacter, Proteus mirabilis, P vulgaris, P morganii, and P rettgeri. Approximately half of these patients experienced mild symptoms possibly related to oxolinic acid therapy; in no instance did they require cessation of therapy.

Our experience indicates that if the urine is not sterile by the end of five days of treatment, bacterial resistance to oxolinic acid is likely to have developed, and therapy with another agent should be considered and antibiotic susceptibility tests repeated.

(Am J Dis Child 131:34-37, 1977)

REFERENCES

ABSTRACT | REFERENCES

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Ringel SM, Turner FJ, Lindo FL, et al: Oxolinic acid: A new synthetic antimicrobial agent . Antimicrob Agents Chemother 7:480-485, 1967;.

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Clark H, Brown NK, Wallace JF, et al: Emergence of resistant organisms as a function of oxolinic acid therapy . Am J Med Sci 261:145-148, 1971;.

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Blazevic DJ, Stemper JE, Matsen JM: Organisms encountered in urine cultures over a ten-year period . Appl Microbiol 23:421-422, 1972;.

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