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November 1976, Vol 130, No. 11 >
Article | November 1976

Pneumonia in the Neonate Associated With Group B Streptococcal Septicemia FREE

Val G. Hemming, MD; Donald W. McCloskey, MD; Harry R. Hill, MD
[+] Author Affiliations

Reprint requests to Department of Pediatrics, University of Utah College of Medicine, Salt Lake City, UT 84132 (Dr Hemming).


Am J Dis Child. 1976;130(11):1231-1233. doi:10.1001/archpedi.1976.02120120065011.
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• Fifteen newborns referred to the University of Utah Neonatal Intensive Care Unit (NICU) between 1971 and 1974 had septicemia and bronchopneumonia caused by streptococci of Lancefield group B. Eight of these infants could not be distinguished from others with idiopathic respiratory distress syndrome. All eight died and at autopsy were found to have bronchopneumonia. At autopsy, five of the ten subjects had bilateral pleural effusions. Eight of these early onset infections were caused by type III strains, three by type II strains, and four by la strains. The three survivors were infected by la organisms; two of these patients received antimicrobial therapy within one hour of birth and the other was treated at 20 hours of age. Among the 12 patients who died, six received no antibiotics and five were treated 12 or more hours after delivery. Earlier recognition may lead to more efficacious therapy of this most fulminant infection of the newborn.

(Am J Dis Child 130:1231-1233, 1976)

REFERENCES

1 +
Lancefield RC:  Serological differentiation of human and other groups of hemolytic streptococci . J Exp Med 57:571-595, 1933;.
2 +
Lancefield RC:  Serological differentiation of specific types of bovine streptococci (group B) . J Exp Med 59:441-458, 1934;.
3 +
Lancefield RC, Hare R:  Serological differentiation of pathogenic and nonpathogenic strains of hemolytic streptococci from parturient women . J Exp Med 61:335-349, 1935;.
4 +
Fry RM:  Fatal infections by haemolytic streptococcus group B . Lancet 1:199-201, 1938;.
5 +
Nyhan WL, Fousek MD:  Septicemia of the newborn . Pediatrics 22:268-278, 1958;.
6 +
Hood M, Janney A, Dameron G:  Beta hemolytic streptococcus group B associated with problems of the neonatal period . Am J Obstet Gynecol 82:809-818, 1961;.
7 +
Eickhoff TC, Klein JO, Daly AH, et al:  Neonatal sepsis and other infections due to group B beta hemolytic streptococci . N Engl J Med 271:1221-1228, 1964;.
8 +
Bergqvist G, Hervell B, Malmborg AS, et al:  Neonatal infections caused by group B strepto cocci . Scand J Infect Dis 3:157-162, 1971;.
9 +
Franciosi RA, Zimmerman RA, Favara BE, et al:  Neonatal infection due to group B streptococcus . Rocky Mt Med J 68:48-52, 1971;.
10 +
Franciosi RA, Knostman JD, Zimmerman RA:  Group B streptococcal neonatal and infant infections . J Pediatr 82:707-718, 1973;.
11 +
Barton LL, Feigin RD, Lins R:  Group B beta-hemolytic streptococcal meningitis in infants . J Pediatr 82:719-723, 1973;.
12 +
Baker CJ, Barrett FF, Gordon RC, et al:  Suppurative meningitis due to streptococci of Lancefield group B: A study of 33 infants . J Pediatr 82:724-729, 1973;.
13 +
Baker CJ, Barrett FF:  Transmission of group B streptococci among parturient women and their neonates . J Pediatr 83:919-925, 1973;.
14 +
Quirante J, Ceballos R, Cassady G:  Group B β-hemolytic streptococcal infection in the newborn: I. Early onset infection . Am J Dis Child 128:659-665, 1974;.
15 +
Howard JB, McCracken GH Jr:  The spectrum of group B streptococcal infections in infancy . Am J Dis Child 128:815-818, 1974;.
16 +
Lancefield RC:  Micro-precipitin-technic for classifying hemolytic streptococci, and improved methods for producing antisera . Proc Soc Exp Biol Med 38:473, 1938;.
17 +
Lancefield RC:  A serological differentiation of specific types of bovine hemolytic streptococci (group B) . J Exp Med 59:441-458, 1934;.
18 +
Hill HR, Riter ME, Menge SK, et al:  Rapid identification of group B streptococci by counterimmunoelectrophoresis . J Clin Microbiol 1:188-191, 1975;.
19 +
Klesius PH, Zimmerman RA, Matthews JH, et al:  Cellular and humoral immune response to group B streptococci . J Pediatr 83:926-932, 1973;.
20 +
Matthews JH, Klesius PH, Zimmerman RA:  Opsonic system of the group B streptococcus . Infect Immun 10:1315-1320, 1974;.
21 +
Hill HR:  Rapid detection and specific identification of infections due to group B streptococci by counterimmunoelectrophoresis , in Schlessinger D (ed): Microbiology 1975 . Washington, DC, American Society for Microbiology, 1975;, pp 84-88.

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References

1 +
Lancefield RC:  Serological differentiation of human and other groups of hemolytic streptococci . J Exp Med 57:571-595, 1933;.
2 +
Lancefield RC:  Serological differentiation of specific types of bovine streptococci (group B) . J Exp Med 59:441-458, 1934;.
3 +
Lancefield RC, Hare R:  Serological differentiation of pathogenic and nonpathogenic strains of hemolytic streptococci from parturient women . J Exp Med 61:335-349, 1935;.
4 +
Fry RM:  Fatal infections by haemolytic streptococcus group B . Lancet 1:199-201, 1938;.
5 +
Nyhan WL, Fousek MD:  Septicemia of the newborn . Pediatrics 22:268-278, 1958;.
6 +
Hood M, Janney A, Dameron G:  Beta hemolytic streptococcus group B associated with problems of the neonatal period . Am J Obstet Gynecol 82:809-818, 1961;.
7 +
Eickhoff TC, Klein JO, Daly AH, et al:  Neonatal sepsis and other infections due to group B beta hemolytic streptococci . N Engl J Med 271:1221-1228, 1964;.
8 +
Bergqvist G, Hervell B, Malmborg AS, et al:  Neonatal infections caused by group B strepto cocci . Scand J Infect Dis 3:157-162, 1971;.
9 +
Franciosi RA, Zimmerman RA, Favara BE, et al:  Neonatal infection due to group B streptococcus . Rocky Mt Med J 68:48-52, 1971;.
10 +
Franciosi RA, Knostman JD, Zimmerman RA:  Group B streptococcal neonatal and infant infections . J Pediatr 82:707-718, 1973;.
11 +
Barton LL, Feigin RD, Lins R:  Group B beta-hemolytic streptococcal meningitis in infants . J Pediatr 82:719-723, 1973;.
12 +
Baker CJ, Barrett FF, Gordon RC, et al:  Suppurative meningitis due to streptococci of Lancefield group B: A study of 33 infants . J Pediatr 82:724-729, 1973;.
13 +
Baker CJ, Barrett FF:  Transmission of group B streptococci among parturient women and their neonates . J Pediatr 83:919-925, 1973;.
14 +
Quirante J, Ceballos R, Cassady G:  Group B β-hemolytic streptococcal infection in the newborn: I. Early onset infection . Am J Dis Child 128:659-665, 1974;.
15 +
Howard JB, McCracken GH Jr:  The spectrum of group B streptococcal infections in infancy . Am J Dis Child 128:815-818, 1974;.
16 +
Lancefield RC:  Micro-precipitin-technic for classifying hemolytic streptococci, and improved methods for producing antisera . Proc Soc Exp Biol Med 38:473, 1938;.
17 +
Lancefield RC:  A serological differentiation of specific types of bovine hemolytic streptococci (group B) . J Exp Med 59:441-458, 1934;.
18 +
Hill HR, Riter ME, Menge SK, et al:  Rapid identification of group B streptococci by counterimmunoelectrophoresis . J Clin Microbiol 1:188-191, 1975;.
19 +
Klesius PH, Zimmerman RA, Matthews JH, et al:  Cellular and humoral immune response to group B streptococci . J Pediatr 83:926-932, 1973;.
20 +
Matthews JH, Klesius PH, Zimmerman RA:  Opsonic system of the group B streptococcus . Infect Immun 10:1315-1320, 1974;.
21 +
Hill HR:  Rapid detection and specific identification of infections due to group B streptococci by counterimmunoelectrophoresis , in Schlessinger D (ed): Microbiology 1975 . Washington, DC, American Society for Microbiology, 1975;, pp 84-88.

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