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Erythrocyte Survival in Children as Studied by Labeling With Stable 50Cr FREE

Chester A. Glomski, MD, PhD; K. K. S. Pillay, PhD; Lorna G. Macdougall, MB, ChB, DCH
[+] Author Affiliations

Reprint requests to Department of Anatomical Sciences, 317 Farber Hall, State University of New York at Buffalo, Buffalo, NY 14214 (Dr Glomski).


Am J Dis Child. 1976;130(11):1228-1230. doi:10.1001/archpedi.1976.02120120062010.
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• The survival of 50Cr- and 51Cr-labeled autologous and/or homologous erythrocytes was compared simultaneously in eight pediatric patients and one adult. 50Cr, a stable, nonradioactive nuclide, had values comparable to those of standard radioactive 51Cr labeling. The data also demonstrated the capability of 50Cr-51Cr labeling to reveal differences in survival between two populations of erythrocytes monitored simultaneously in the same individual. The technique permitted the use of the nonradioactive isotope in volumes of blood that are appropriate for the pediatric age group.

(Am J Dis Child 130:1228-1230, 1976)

REFERENCES

Donaldson GWK, Johnson PF, Tothill P, et al:  Red cell survival time in man measured by 50Cr and activation analysis . Br Med J 2:585-587, 1968;.
Johnson PF, Tothill P, Donaldson GWK:  Stable chromium as a tracer for red cells, with assay by neutron activation analysis . Int J Appl Radiat Isot 20:103-108, 1969;.
Glomski CA, Pillay SKK:  Tissue distribution and quantitation of stable Cr50 derived from labeled erythrocytes . J Med 1:165-173, 1970;.
Glomski CA, Pillay SKK, Hagle RE:  Survival of 50Cr-labeled erythrocytes as studied by instrumental activation analysis . J Nucl Med 12:31-34, 1971;.
Macdougall LG, Judisch JM, Mistry SB:  Red cell metabolism in iron deficiency anemia: II. The relationship between red cell survival and alterations in red cell metabolism . J Pediatr 76:660-675, 1970;.
Dyer NC, Brill AB, Tsiantos AK, et al:  Timing of intracranial bleeding in newborn infants . J Nucl Med 14:807-811, 1973;.
Pillay KKS, Thomas CC Jr, Hyche CM:  Neutron activation analysis of some of the biologically active trace elements in fish . J Radioanal Chem 20:597-606, 1974;.

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References

Donaldson GWK, Johnson PF, Tothill P, et al:  Red cell survival time in man measured by 50Cr and activation analysis . Br Med J 2:585-587, 1968;.
Johnson PF, Tothill P, Donaldson GWK:  Stable chromium as a tracer for red cells, with assay by neutron activation analysis . Int J Appl Radiat Isot 20:103-108, 1969;.
Glomski CA, Pillay SKK:  Tissue distribution and quantitation of stable Cr50 derived from labeled erythrocytes . J Med 1:165-173, 1970;.
Glomski CA, Pillay SKK, Hagle RE:  Survival of 50Cr-labeled erythrocytes as studied by instrumental activation analysis . J Nucl Med 12:31-34, 1971;.
Macdougall LG, Judisch JM, Mistry SB:  Red cell metabolism in iron deficiency anemia: II. The relationship between red cell survival and alterations in red cell metabolism . J Pediatr 76:660-675, 1970;.
Dyer NC, Brill AB, Tsiantos AK, et al:  Timing of intracranial bleeding in newborn infants . J Nucl Med 14:807-811, 1973;.
Pillay KKS, Thomas CC Jr, Hyche CM:  Neutron activation analysis of some of the biologically active trace elements in fish . J Radioanal Chem 20:597-606, 1974;.

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