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Fetal Malformations and Antiepileptic Drugs

REBA MICHELS HILL, MD
Am J Dis Child. 1976;130(9):923-925. doi:10.1001/archpedi.1976.02120100013002.
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Infants born to mothers with a seizure disorder have now been identified as being at risk for congenital malformations. These observations have been made by investigators throughout the world, as demonstrated by articles by Goodman et al in the August issue of the Journal (130:884-887, 1976), from Ramat Aviv and in this issue by Waziri et al (p 1022) from Iowa. The incidence of congenital malformations in treated mothers is two to three times normal.1.2 Monson and Rosenberg3 reported the incidence of a select group of malformations in infants born to untreated seizure patients to be similar to those occurring in a cohort group of infants born to nonseizure patients (29.5/1,000 vs 24.5/1,000). On the other hand, Janz's4 survey of the world literature revealed an increased incidence of congenital malformations in infants born to untreated seizure patients, 4.2% compared to a control population of 2.5%.

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