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August 1976, Vol 130, No. 8 >
Article | August 1976

Hyperuricemia in the Hemolytic-Uremic Syndrome FREE

Bernard S. Kaplan, MD, BCh, FCP(SA); Peter D. Thomson, MB, BCh, FCP(SA)
[+] Author Affiliations

Received for publication March 20, 1975; accepted July 9.

Reprint requests to Department of Nephrology, Montreal Children's Hospital, 2300 Tupper St, Montreal, Quebec, Canada (Dr Kaplan).


Am J Dis Child. 1976;130(8):854-856. doi:10.1001/archpedi.1976.02120090064011.
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References
Comments

• Elevated serum uric acid concentrations were found in 18 children with hemolytic-uremic syndrome. The highest recorded level in each patient ranged from 10 to 29 mg/100 ml, and nine patients had concentrations of greater than 20 mg/100 ml. During a 53-hour period of peritoneal dialysis, 5.5 gm of uric acid was removed from one infant. Although acute renal failure was probably the major factor, erythrocyte destruction and hyperlacticacidemia may also have been important in the pathogenesis of the hyperuricemia.

(Am J Dis Child 130:854-856, 1976)

REFERENCES

1 +
Schrier RW, Hano J, Keller HI, et al:  Renal, metabolic, and circulatory responses to heat and exercise . Ann Intern Med 73:213-223, 1970;.
2 +
Lieberman E:  Hemolytic-uremic syndrome . J Pediatr 80:1-16, 1972;.
3 +
Royer P:  Hyperuricemia in children, with the exception of the Lesch-Nyhan syndrome , in Hamburger J, Croshier J, Maxwell MH (eds): Advances in Nephrology . Chicago, Year Book Medical Publishers Inc, 1974;, vol 3, pp 71-79.
4 +
Caraway MT, Marable H:  Comparison of carbonate and uricasecarbonate methods for the determination of uric acid in serum . Clin Chem 12:18-24, 1966;.
5 +
Archibald RM:  Colorimetic measurement of uric acid . Clin Chem 3:102-105, 1957;.
6 +
Kaplan BS, Katz J, Krawitz S, et al:  An analysis of the results of therapy in 67 cases of the hemolytic uremic syndrome . J Pediatr 78:420-425, 1971;.
7 +
Kaplan BS, Chesney RW, Drummond KN:  Hemolytic uremic syndrome in families . N Engl J Med 292:1090-1093.
8 +
Kelley WN, Grobner W, Holmes E:  Current concepts in the pathogenesis of hyperuricemia . Metabolism 22:939-959, 1973;.
9 +
Walker BR, Alexander F:  Uric acid excretion in sickle cell anemia . JAMA 215:255-258, 1971;.
10 +
Nolph KD, Whitcomb M, Schrier RW:  Mechanism of inefficient peritoneal dialysis in acute renal failure associated with heat stress and exercise . Ann Intern Med 71:317-326, 1969;.
11 +
Handler JS:  Role of lactic acid in reduced excretion of uric acid in toxemia of pregnancy . J Clin Invest 39:1526-1532, 1960;.
12 +
Wiedemann E, Rose HG, Schwartz E:  Plasma lipoproteins glucose tolerance and insulin response in primary gout . Am J Med 53:299-307, 1972;.
13 +
Kaplan BS, Gale D, Ipp T:  Hyperlipidemia in the hemolytic-uremic syndrome . Pediatrics 47:777-779, 1971;.
14 +
Weintraub LR, Penner JA, Meyers MC:  Acute uric acid nephropathy in leukemia . Arch Intern Med 113:111-114, 1964;.
15 +
Passwell J, Boichis H, Cohen BE:  Hyperuricemic nephropathy . Am J Dis Child 120:154-156, 1970;.
16 +
Epstein FH, Pigeon G:  Experimental urate nephropathy: Studies on the distribution of urate in renal tissue . Nephron 1:144-157, 1964;.
17 +
Smith JF, Lee YC:  Experimental uric acid nephritis in the rabbit . J Exp Med 105:615-621, 1957;.
18 +
Koletsky S:  Hypertensive vascular disease produced by salt . Lab Invest 7:377-386, 1958;.
19 +
Brentijens JRH, Vreeken J, Feltkamp-Vroom T, et al:  Pyelonephritis-like lesions as a late effect of diffuse intravascular coagulation . Acta Med Scand 183:203-208, 1968;.
20 +
Fox M:  Progressive renal fibrosis following acute tubular necrosis: An experimental study . J Urol 97:196-202, 1967;.
21 +
Deger GF, Wagoner RD:  Peritoneal dialysis in acute uric acid nephropathy . Mayo Clin Proc 47:189-192, 1972;.

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References

1 +
Schrier RW, Hano J, Keller HI, et al:  Renal, metabolic, and circulatory responses to heat and exercise . Ann Intern Med 73:213-223, 1970;.
2 +
Lieberman E:  Hemolytic-uremic syndrome . J Pediatr 80:1-16, 1972;.
3 +
Royer P:  Hyperuricemia in children, with the exception of the Lesch-Nyhan syndrome , in Hamburger J, Croshier J, Maxwell MH (eds): Advances in Nephrology . Chicago, Year Book Medical Publishers Inc, 1974;, vol 3, pp 71-79.
4 +
Caraway MT, Marable H:  Comparison of carbonate and uricasecarbonate methods for the determination of uric acid in serum . Clin Chem 12:18-24, 1966;.
5 +
Archibald RM:  Colorimetic measurement of uric acid . Clin Chem 3:102-105, 1957;.
6 +
Kaplan BS, Katz J, Krawitz S, et al:  An analysis of the results of therapy in 67 cases of the hemolytic uremic syndrome . J Pediatr 78:420-425, 1971;.
7 +
Kaplan BS, Chesney RW, Drummond KN:  Hemolytic uremic syndrome in families . N Engl J Med 292:1090-1093.
8 +
Kelley WN, Grobner W, Holmes E:  Current concepts in the pathogenesis of hyperuricemia . Metabolism 22:939-959, 1973;.
9 +
Walker BR, Alexander F:  Uric acid excretion in sickle cell anemia . JAMA 215:255-258, 1971;.
10 +
Nolph KD, Whitcomb M, Schrier RW:  Mechanism of inefficient peritoneal dialysis in acute renal failure associated with heat stress and exercise . Ann Intern Med 71:317-326, 1969;.
11 +
Handler JS:  Role of lactic acid in reduced excretion of uric acid in toxemia of pregnancy . J Clin Invest 39:1526-1532, 1960;.
12 +
Wiedemann E, Rose HG, Schwartz E:  Plasma lipoproteins glucose tolerance and insulin response in primary gout . Am J Med 53:299-307, 1972;.
13 +
Kaplan BS, Gale D, Ipp T:  Hyperlipidemia in the hemolytic-uremic syndrome . Pediatrics 47:777-779, 1971;.
14 +
Weintraub LR, Penner JA, Meyers MC:  Acute uric acid nephropathy in leukemia . Arch Intern Med 113:111-114, 1964;.
15 +
Passwell J, Boichis H, Cohen BE:  Hyperuricemic nephropathy . Am J Dis Child 120:154-156, 1970;.
16 +
Epstein FH, Pigeon G:  Experimental urate nephropathy: Studies on the distribution of urate in renal tissue . Nephron 1:144-157, 1964;.
17 +
Smith JF, Lee YC:  Experimental uric acid nephritis in the rabbit . J Exp Med 105:615-621, 1957;.
18 +
Koletsky S:  Hypertensive vascular disease produced by salt . Lab Invest 7:377-386, 1958;.
19 +
Brentijens JRH, Vreeken J, Feltkamp-Vroom T, et al:  Pyelonephritis-like lesions as a late effect of diffuse intravascular coagulation . Acta Med Scand 183:203-208, 1968;.
20 +
Fox M:  Progressive renal fibrosis following acute tubular necrosis: An experimental study . J Urol 97:196-202, 1967;.
21 +
Deger GF, Wagoner RD:  Peritoneal dialysis in acute uric acid nephropathy . Mayo Clin Proc 47:189-192, 1972;.

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