0
August 1976, Vol 130, No. 8 >
Article | August 1976

Sweat Gland Reactivity to Local Thermal Stimulation in Dysautonomia FREE

Marvin Green, MD; Hans Behrendt, MD
[+] Author Affiliations

Received for publication Jan 31,1975; accepted April 23.

Reprint requests to Department of Pediatrics, New York Medical College, 1249 Fifth Ave, New York, NY 10029 (Dr Green).


Am J Dis Child. 1976;130(8):816-818. doi:10.1001/archpedi.1976.02120090026005.
Text Size: A A A
Published online
Article
References
Comments

• An attempt has been made to elucidate the cause of hyperhidrosis in dysautonomia by testing sweat gland responsiveness to local application of heat. Heat was applied to the volar surface of the forearm with temperatures of 41.5 C and less for one to ten minutes. For each subject, the minimal duration of heating at the lowest temperature capable of evoking sweating was determined (threshold). Thresholds were significantly lower in all subjects with dysautonomia. Since one control subject, the father of a dysautonomia subject, had the highest threshold, these tests do not permit detection of the heterozygote.

A reasonable explanation for enhanced sweating reactivity to local heat application is an increased excitatory state of reflex centers. These patients appear permanently on the verge of generalized sweating likely to result from minimal additional stimulation.

(Am J Dis Child 130:816-818, 1976)

REFERENCES

1 +
Riley CM:  Familial dysautonomia . Adv Pediatr 9:157-190, 1957;.
2 +
Green M, Smith AA:  Comparative axon reflex responses in familial dysautonomia . J Appl Physiol 28:790-792, 1970;.
3 +
McLaughlin MD, Sonnenschein RR:  Responses of human sweat glands to local heating . J Invest Dermatol 41:27-29, 1963;.
4 +
Green M, Behrendt H:  Sweating responses of neonates to local thermal stimulation . Am J Dis Child 125:20-25, 1973;.
5 +
Sakurai M, Montagna W:  Pharmacologic properties of the sweat gland of Lemur mongoz . J Invest Dermatol 42:411-414, 1964;.
6 +
Wada M:  Sudorific action of adrenalin on the human sweat glands and determination of their excitability . Science 111:376-377, 1950;.
7 +
Benjamin FB:  Sweating response to local heat application . J Appl Physiol 5:594-598, 1953;.
8 +
Issekutz B, Hetenyi G, Diosy A:  Contributions to the physiology of sweat secretion . Arch Int Pharmacodyn Ther 83:133-142, 1950;.
9 +
MacIntyre BA, Bullard RW, Banerjee M, et al:  Mechanism of enhancement of eccrine sweating by localized heating . J Appl Physiol 25:255-260, 1968;.
10 +
Brown WJ, Beauchemin JA, Linde LM:  Neuropathological study of familial dysautonomia (Riley-Day Syndrome) in siblings . J Neurol Neurosurg Psychiatry 27:131-139, 1964;.
11 +
Cannon WB, Rosenblueth A: The Supersensitivity of Denervated Structures (A Law of Denervation) . New York, Macmillan Co, 1949;, pp 11-21.
12 +
Dancis J, Smith A:  Current concepts in familial dysautonomia . N Engl J Med 274:207-209, 1966;.
13 +
Smith A, Dancis J:  Response to intradermal histamine in familial dysautonomia: Diagnostic test . J Pediatr 63:889-894, 1963;.
14 +
Smith A, Dancis J, Breinin G:  Ocular responses to autonomic drugs in familial dysautonomia . Invest Ophthalmol 4:358-361, 1965;.
15 +
Montagna W: The Structure and Function of the Skin . New York, Academic Press, 1962;, p 366.

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Riley CM:  Familial dysautonomia . Adv Pediatr 9:157-190, 1957;.
2 +
Green M, Smith AA:  Comparative axon reflex responses in familial dysautonomia . J Appl Physiol 28:790-792, 1970;.
3 +
McLaughlin MD, Sonnenschein RR:  Responses of human sweat glands to local heating . J Invest Dermatol 41:27-29, 1963;.
4 +
Green M, Behrendt H:  Sweating responses of neonates to local thermal stimulation . Am J Dis Child 125:20-25, 1973;.
5 +
Sakurai M, Montagna W:  Pharmacologic properties of the sweat gland of Lemur mongoz . J Invest Dermatol 42:411-414, 1964;.
6 +
Wada M:  Sudorific action of adrenalin on the human sweat glands and determination of their excitability . Science 111:376-377, 1950;.
7 +
Benjamin FB:  Sweating response to local heat application . J Appl Physiol 5:594-598, 1953;.
8 +
Issekutz B, Hetenyi G, Diosy A:  Contributions to the physiology of sweat secretion . Arch Int Pharmacodyn Ther 83:133-142, 1950;.
9 +
MacIntyre BA, Bullard RW, Banerjee M, et al:  Mechanism of enhancement of eccrine sweating by localized heating . J Appl Physiol 25:255-260, 1968;.
10 +
Brown WJ, Beauchemin JA, Linde LM:  Neuropathological study of familial dysautonomia (Riley-Day Syndrome) in siblings . J Neurol Neurosurg Psychiatry 27:131-139, 1964;.
11 +
Cannon WB, Rosenblueth A: The Supersensitivity of Denervated Structures (A Law of Denervation) . New York, Macmillan Co, 1949;, pp 11-21.
12 +
Dancis J, Smith A:  Current concepts in familial dysautonomia . N Engl J Med 274:207-209, 1966;.
13 +
Smith A, Dancis J:  Response to intradermal histamine in familial dysautonomia: Diagnostic test . J Pediatr 63:889-894, 1963;.
14 +
Smith A, Dancis J, Breinin G:  Ocular responses to autonomic drugs in familial dysautonomia . Invest Ophthalmol 4:358-361, 1965;.
15 +
Montagna W: The Structure and Function of the Skin . New York, Academic Press, 1962;, p 366.

Correspondence

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems