It is but natural that Dorothy Villee would have written a developmental approach to human endocrinology. Her long interest and expertise in the field of perinatal steroidology admirably prepared her for this accomplishment. The explosive nature of recent knowledge regarding the biochemistry of the fetoplacental unit has made putting together the pieces of the puzzle difficult at times, and Dr Villee has integrated this into a clear discussion in the early chapters of her book. The presentation begins with fertilization and the subsequent early events of embryogenesis, leading directly into a consideration of the placenta and its hormonology. This is followed by a description of the development of the endocrine glands of the fetus and the endocrine control of fetal metabolism and differentiation. Such an organized essay on this fascinating area of human development has been long overdue.
The chapter on endocrine and metabolic changes in the perinatal period reflects