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January 1976, Vol 130, No. 1 >
Article | January 1976

Acute Athetosis as a Result of Phenytoin Toxicity in a Child FREE

Stephen Zinsmeister, MD; Richard E. Marks, MD
[+] Author Affiliations

Received for publication Sept 12, 1974; accepted Jan 17, 1975.

Reprint requests to Division of Neurology, Department of Medicine RR 650, University Hospital RG 20, University of Washington, Seattle, WA 98195 (Dr Marks).


Am J Dis Child. 1976;130(1):75-76. doi:10.1001/archpedi.1976.02120020077015.
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Comments

• A case of acute athetosis in a child was found to be related to phenytoin toxicity. Symptoms were intermittent and coincided with drug administration. More common toxic effects were not noted on initial evaluation of the patient.

(Am J Dis Child 130:75-76, 1976)

REFERENCES

1 +
Livingston S: Comprehensive Management of Epilepsy in Infancy, Childhood, and Adolescence . Springfield, Ill, Charles C Thomas Publisher 1972;, pp 201-217.
2 +
Patel H, Crichton JU:  The neurologic hazards of diphenylhydantoin in childhood . J Pediatr 73:676-684, 1968;.
3 +
Kooiker JC, Sumi SM:  Movement disorder as a manifestation of diphenylhydantoin intoxication . Neurology 24:68-71, 1974;.
4 +
Logan WJ, Freeman JM:  Pseudodegenerative disease due to diphenylhydantoin intoxication . Arch Neurol 21:631-637, 1969;.
5 +
Gerber N, Lynn R, Oates J:  Acute intoxication with 5,5-diphenylhydantoin (Dilantin) associated with impairment of biotransformation . Ann Intern Med 77:765-771, 1972;.
6 +
Peters HA, Eichman PL, Price JM, et al:  Abnormal copper and tryptophan metabolism and chelation therapy in anticonvulsant drug intolerance . Dis Nerv Syst 28:97-107, 1966;.
7 +
Ausmar J:  New developments in anticonvulsant therapy . Postgrad Med 47:122-127, 1970;.
8 +
Stanbury JB, Wyngaarden JB, Fredrickson DS: The Metabolic Basis of Inherited Disease , ed 3. New York, McGraw-Hill Book Co Inc, 1972;, pp 382, 436, 1486.
9 +
Goodman L, Gilman A: The Pharmacological Basis of Therapeutics , ed 3. Toronto, Macmillian Co, 1965;, pp 225-226.
10 +
Grollman A, Grollman E: Pharmacology and Therapeutics , ed 7. Philadelphia, Lea & Febiger 1970;, pp 187-188.
11 +
Kutt H, Penry JK:  Usefulness of blood levels of antiepileptic drugs . Arch Neurol 31:283-288, 1974;.

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References

1 +
Livingston S: Comprehensive Management of Epilepsy in Infancy, Childhood, and Adolescence . Springfield, Ill, Charles C Thomas Publisher 1972;, pp 201-217.
2 +
Patel H, Crichton JU:  The neurologic hazards of diphenylhydantoin in childhood . J Pediatr 73:676-684, 1968;.
3 +
Kooiker JC, Sumi SM:  Movement disorder as a manifestation of diphenylhydantoin intoxication . Neurology 24:68-71, 1974;.
4 +
Logan WJ, Freeman JM:  Pseudodegenerative disease due to diphenylhydantoin intoxication . Arch Neurol 21:631-637, 1969;.
5 +
Gerber N, Lynn R, Oates J:  Acute intoxication with 5,5-diphenylhydantoin (Dilantin) associated with impairment of biotransformation . Ann Intern Med 77:765-771, 1972;.
6 +
Peters HA, Eichman PL, Price JM, et al:  Abnormal copper and tryptophan metabolism and chelation therapy in anticonvulsant drug intolerance . Dis Nerv Syst 28:97-107, 1966;.
7 +
Ausmar J:  New developments in anticonvulsant therapy . Postgrad Med 47:122-127, 1970;.
8 +
Stanbury JB, Wyngaarden JB, Fredrickson DS: The Metabolic Basis of Inherited Disease , ed 3. New York, McGraw-Hill Book Co Inc, 1972;, pp 382, 436, 1486.
9 +
Goodman L, Gilman A: The Pharmacological Basis of Therapeutics , ed 3. Toronto, Macmillian Co, 1965;, pp 225-226.
10 +
Grollman A, Grollman E: Pharmacology and Therapeutics , ed 7. Philadelphia, Lea & Febiger 1970;, pp 187-188.
11 +
Kutt H, Penry JK:  Usefulness of blood levels of antiepileptic drugs . Arch Neurol 31:283-288, 1974;.

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