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December 1975, Vol 129, No. 12 >
Article | December 1975

Aspirin Hepatitis FREE

Preston Zucker, MD; Fredric Daum, MD; Michael I. Cohen, MD
[+] Author Affiliations

Received for publication Dec 23, 1974; accepted Jan 21, 1975.

Reprint requests to the Department of Pediatrics, Montefiore Hospital and Medical Center, 111 E 210th St, Bronx, NY 10467 (Dr Zucker).


Am J Dis Child. 1975;129(12):1433-1434. doi:10.1001/archpedi.1975.02120490045014.
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• Adverse reactions to aspirin, a potentially hepatotoxic drug, are believed to be dose related. This article reviews the medical literature and describes two children with aspirin hepatitis. Hepatic dysfunction recurred in one of these patients at salicylate concentrations in serum previously considered nontoxic.

(Am J Dis Child 129:1433-1434, 1975)

REFERENCES

1 +
Manso C, Taranta A, Nydick I:  Effect of aspirin administration on serum glutamic oxaloacetic and glutamic pyruvic transaminases in children . Proc Soc Exp Biol Med 93:84-88, 1956;.
2 +
Russell A, Stunge R, Smith M:  Serum transaminases during salicylate therapy . Br Med J 2:428-449, 1971;.
3 +
Rich R, Johnson J:  Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis . Arthritis Rheum 16:1-9, 1973;.
4 +
Seaman W, Ishak K, Plotz P:  Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus . Ann Intern Med 80:1-8, 1974;.
5 +
 Does aspirin harm the liver?  editorial. Lancet 1:667, 1974;.
6 +
Schaffner F:  Some unresolved ultrastructural problems encountered in the study of the liver and its diseases , in Schaffner F, Sherlock S, Leevy C (eds): The Liver and Its Diseases . New York, Intercontinental Medical Book Corp, 1974;, pp 7-8.
7 +
Mitchell J, Jollow D, Potter W, et al:  Acetaminophen-induced hepatic necrosis: IV. Protective role of glutathione . J Pharmacol Exp Ther 187:211-217, 1973;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Manso C, Taranta A, Nydick I:  Effect of aspirin administration on serum glutamic oxaloacetic and glutamic pyruvic transaminases in children . Proc Soc Exp Biol Med 93:84-88, 1956;.
2 +
Russell A, Stunge R, Smith M:  Serum transaminases during salicylate therapy . Br Med J 2:428-449, 1971;.
3 +
Rich R, Johnson J:  Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis . Arthritis Rheum 16:1-9, 1973;.
4 +
Seaman W, Ishak K, Plotz P:  Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus . Ann Intern Med 80:1-8, 1974;.
5 +
 Does aspirin harm the liver?  editorial. Lancet 1:667, 1974;.
6 +
Schaffner F:  Some unresolved ultrastructural problems encountered in the study of the liver and its diseases , in Schaffner F, Sherlock S, Leevy C (eds): The Liver and Its Diseases . New York, Intercontinental Medical Book Corp, 1974;, pp 7-8.
7 +
Mitchell J, Jollow D, Potter W, et al:  Acetaminophen-induced hepatic necrosis: IV. Protective role of glutathione . J Pharmacol Exp Ther 187:211-217, 1973;.

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