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Clinical Evaluation of a New Measles-Mumps-Rubella Trivalent Vaccine

Anton J. F. Schwarz, MD; Joseph E. Jackson, MD, DrPH; N. Joel Ehrenkranz, MD; Arnoldo Ventura, PhD; Gilbert M. Schiff, MD; Vernon W. Walters, MD
Am J Dis Child. 1975;129(12):1408-1412. doi:10.1001/archpedi.1975.02120490026008.
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• In a series of clinical studies of a combined measles (Schwarz strain), mumps (Jeryl Lynn strain), and rubella (Cendehill strain) vaccine, 1,481 children received the vaccine or a placebo. The vaccine did not cause any significant reactions. The frequencies of mild, transient fever or rash or both in triple-susceptible vaccinees were similar to those that follow use of Schwarz strain measles vaccine alone. Measles, mumps, and rubella seroconversion rates in triple-susceptible vaccinees ranged from 95% to 100%. Geometric mean antibody titers were as high as those that usually result from use of these same virus strains as monovalent vaccines.

(Am J Dis Child 129:1408-1412, 1975)

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