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August 1975, Vol 129, No. 8 >
Article | August 1975

Maternal Phenytoin Ingestion and Congenital Abnormalities: Report of a Case FREE

MOSHE HIRSCHBERGER, MD; FREDRIC KLEINBERG, MD
Am J Dis Child. 1975;129(8):984. doi:10.1001/archpedi.1975.02120450086021.
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The first reported association of congenital malformations and anticonvulsant drugs was published in 1968.1 Cleft lip and cleft palate were reported in six infants born to mothers who had been taking anticonvulsants during pregnancy. Monson et al2 compared the frequency of malformations in infants exposed in utero to antiepileptic medication with that in infants not so exposed. In their study, the malformation rate among children exposed to phenytoin (formerly diphenylhydantoin) sodium continuously during embryonic and early fetal development was 61 in 1,000 live births. This rate is higher than the 25 in 1,000 live births in children born to normal control women. The possibility of having a malformed child appears to be two to three times greater in epileptic women who received phenytoin continuously early in pregnancy than in normal women. This frequency of malformations has been confirmed by other studies.3,4

In most reports, cleft lip and

REFERENCES

1 +
Meadow SR:  Anticonvulsant drugs and congenital abnormalities . Lancet 2:1296, 1968;.
2 +
Monson RR, Rosenberg L, Hartz SC, et al:  Malformations . N Engl J Med 289:1049-1052, 1973;.
3 +
Lowe CR:  Congenital malformations among infants born to epileptic women . Lancet 1:9-10, 1973;.
4 +
Fedrick J:  Epilepsy and pregnancy: A report from the Oxford record linkage study . Br Med J 2:442-448, 1973;.
5 +
Hill RM, Verniaud WM, Horning MG, et al:  Infants exposed in utero to antiepileptic drugs: A prospective study . Am J Dis Child 127:645-653, 1974;.
6 +
Way HB, Hermann J, Gilbert EF, et al:  Cutis marmorata telangiectatica congenita . J Cutaneous Pathol 1:10-25, 1974;.
7 +
Uson AC, Lattimer JK, Melicow MM:  Types of exstrophy of urinary bladder and concomitant malformations: A report based on 82 cases . Pediatrics 23:927-934, 1959;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Meadow SR:  Anticonvulsant drugs and congenital abnormalities . Lancet 2:1296, 1968;.
2 +
Monson RR, Rosenberg L, Hartz SC, et al:  Malformations . N Engl J Med 289:1049-1052, 1973;.
3 +
Lowe CR:  Congenital malformations among infants born to epileptic women . Lancet 1:9-10, 1973;.
4 +
Fedrick J:  Epilepsy and pregnancy: A report from the Oxford record linkage study . Br Med J 2:442-448, 1973;.
5 +
Hill RM, Verniaud WM, Horning MG, et al:  Infants exposed in utero to antiepileptic drugs: A prospective study . Am J Dis Child 127:645-653, 1974;.
6 +
Way HB, Hermann J, Gilbert EF, et al:  Cutis marmorata telangiectatica congenita . J Cutaneous Pathol 1:10-25, 1974;.
7 +
Uson AC, Lattimer JK, Melicow MM:  Types of exstrophy of urinary bladder and concomitant malformations: A report based on 82 cases . Pediatrics 23:927-934, 1959;.

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