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Infectious Arthritis in the Neonate Caused by Haemophilus influenzae FREE

Dan M. Granoff, MD; George A. Nankervis, PhD, MD
[+] Author Affiliations

Received for publication Aug 27, 1974; accepted Sept 16.

Reprint requests to Department of Pediatrics, Cleveland Metropolitan General Hospital, 3395 Scranton Rd, Cleveland, OH 44109 (Dr. Granoff).


Am J Dis Child. 1975;129(6):730-733. doi:10.1001/archpedi.1975.02120430062017.
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Two newborns had hematogenous pyarthrosis due to Haemophilus influenzae. One infant had signs of sepsis and dactylitis involving several fingers and toes. She also developed a soft tissue abscess, meningitis, and a septic hip, and was found to be infected with a nontypable organism. In the second infant, a shoulder traumatized at birth became infected with a type b strain. In both cases, the patients were successfully treated, but delays occurred in selecting the optimal therapeutic agent because of failure to appreciate that Haemophilus may cause systemic infection in the newborn. In the first infant the source of the infection was identified as the mother's endocervical canal. This patient is also of interest because in contrast to previous reports of Haemophilus infection in the newborn, bactericidal activity was present in the maternal serum.

REFERENCES

Fothergill LD, Wright J:  Influenzal meningitis: The relation of age incidence to the bactericidal power of blood against the causal organism . J Immunol 24:273-284, 1933;.
Mathies AW, Hogman J, Ivler D:  Hemophilus influenzae meningitis in a premature infant . Pediatrics 35:791-792, 1965;.
Myhre EB:  Typing of Hemophilus influenzae by counter-immunoelectrophoresis . Acta Pathol Microbiol Scand (B) 82:164-166, 1974;.
Rammelkamp CH:  A method for determining the concentration of penicillin in body fluids and exudates . Proc Soc Exp Biol Med 51:95-97, 1942;.
Davis DJ:  Influenzal meningitis . Arch Intern Med 4:323-329, 1909;.
Link to Article
Groover RV, Sutherland JM, Landing BH:  Purulent meningitis of newborn infants: Eleven-year experience in the antibiotic era . N Engl J Med 264:1115-1121, 1961;.
Link to Article
Gullekson EH, Dumoff M:  Haemophilus parainfluenzae meningitis in a newborn . JAMA 198:1221, 1966;.
Link to Article
Collier AM, Connor JD, Nyhan WL:  Systemic infection with Hemophilus influenzae in very young infants . J Pediatr 70:539-547, 1967;.
Link to Article
Ingman MJ:  Neonatal Hemophilus influenzae septicemia: Originating from maternal amnionitis . Am J Dis Child 119:66-67, 1970;.
Zinner SH, Mc Cormack WM, Lee YH:  Puerperal bacteremia and neonatal sepsis due to Hemophilus parainfluenzae: Report of a case with antibody titers . Pediatrics 49:612-614, 1972;.
Nelson JD:  The bacterial etiology and antibiotic management of septic arthritis in infants and children . Pediatrics 50:437-440, 1972;.
Rogers KB, Zinnemann K, Foster WP:  The isolation and identification of Haemophilus spp. from unusual lesions in children . J Clin Pathol 13:519-524, 1960;.
Link to Article
Feigin RD, Shackelford PG, Keeney R:  Hemophilus influenzae abscess associated with septicemia . Am J Dis Child 121:534-535, 1971;.
Mpairwe Y:  Immunity to Haemophilus influenzae type b: The nature of the bactericidal antibody in human blood . Med Microbiol 4:43-49, 1971;.
Link to Article
Smith DH, Hahn S, Howie VM, et al:  Studies on the prevalence of antibodies to Hemophilus influenzae , in Sell S, Karzon D (eds): Hemophilus influenzae . Nashville, Tenn, Vanderbilt University Press, 1973;, pp 203-213.
Anderson P, Johnston RB, Smith DH:  Human serum activities against Hemophilus influenzae type b . J Clin Invest 51:31-38, 1972;.
Link to Article
Mpairwe Y:  Detection of H. influenzae type b bactericidal antibodies . J Pediatr 80:1064, 1972;.
Norden CW:  Variable susceptibility of Hemophilus influenzae type b strains to serum bactericidal activity . Proc Soc Exp Biol Med 139:59-61, 1972;.
Newman SL, Waldo B, Johnston RB:  Separation of serum bactericidal and opsonizing activities for Haemophilus influenzae type b . Infect Immunity 8:488-490, 1973;.
Granoff DM, Roskes S:  Urinary tract infection due to Hemophilus influenzae, type b . J Pediatr 84:414-416, 1974;.
Link to Article

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References

Fothergill LD, Wright J:  Influenzal meningitis: The relation of age incidence to the bactericidal power of blood against the causal organism . J Immunol 24:273-284, 1933;.
Mathies AW, Hogman J, Ivler D:  Hemophilus influenzae meningitis in a premature infant . Pediatrics 35:791-792, 1965;.
Myhre EB:  Typing of Hemophilus influenzae by counter-immunoelectrophoresis . Acta Pathol Microbiol Scand (B) 82:164-166, 1974;.
Rammelkamp CH:  A method for determining the concentration of penicillin in body fluids and exudates . Proc Soc Exp Biol Med 51:95-97, 1942;.
Davis DJ:  Influenzal meningitis . Arch Intern Med 4:323-329, 1909;.
Link to Article
Groover RV, Sutherland JM, Landing BH:  Purulent meningitis of newborn infants: Eleven-year experience in the antibiotic era . N Engl J Med 264:1115-1121, 1961;.
Link to Article
Gullekson EH, Dumoff M:  Haemophilus parainfluenzae meningitis in a newborn . JAMA 198:1221, 1966;.
Link to Article
Collier AM, Connor JD, Nyhan WL:  Systemic infection with Hemophilus influenzae in very young infants . J Pediatr 70:539-547, 1967;.
Link to Article
Ingman MJ:  Neonatal Hemophilus influenzae septicemia: Originating from maternal amnionitis . Am J Dis Child 119:66-67, 1970;.
Zinner SH, Mc Cormack WM, Lee YH:  Puerperal bacteremia and neonatal sepsis due to Hemophilus parainfluenzae: Report of a case with antibody titers . Pediatrics 49:612-614, 1972;.
Nelson JD:  The bacterial etiology and antibiotic management of septic arthritis in infants and children . Pediatrics 50:437-440, 1972;.
Rogers KB, Zinnemann K, Foster WP:  The isolation and identification of Haemophilus spp. from unusual lesions in children . J Clin Pathol 13:519-524, 1960;.
Link to Article
Feigin RD, Shackelford PG, Keeney R:  Hemophilus influenzae abscess associated with septicemia . Am J Dis Child 121:534-535, 1971;.
Mpairwe Y:  Immunity to Haemophilus influenzae type b: The nature of the bactericidal antibody in human blood . Med Microbiol 4:43-49, 1971;.
Link to Article
Smith DH, Hahn S, Howie VM, et al:  Studies on the prevalence of antibodies to Hemophilus influenzae , in Sell S, Karzon D (eds): Hemophilus influenzae . Nashville, Tenn, Vanderbilt University Press, 1973;, pp 203-213.
Anderson P, Johnston RB, Smith DH:  Human serum activities against Hemophilus influenzae type b . J Clin Invest 51:31-38, 1972;.
Link to Article
Mpairwe Y:  Detection of H. influenzae type b bactericidal antibodies . J Pediatr 80:1064, 1972;.
Norden CW:  Variable susceptibility of Hemophilus influenzae type b strains to serum bactericidal activity . Proc Soc Exp Biol Med 139:59-61, 1972;.
Newman SL, Waldo B, Johnston RB:  Separation of serum bactericidal and opsonizing activities for Haemophilus influenzae type b . Infect Immunity 8:488-490, 1973;.
Granoff DM, Roskes S:  Urinary tract infection due to Hemophilus influenzae, type b . J Pediatr 84:414-416, 1974;.
Link to Article

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