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February 1975, Vol 129, No. 2 >
Article | February 1975

Lack of Abnormalities in a Newborn Exposed to Amphetamine During Gestation FREE

Gerald G. Briggs, Pharm BP; John H. Samson, MD; Donald J. Crawford, MD
[+] Author Affiliations

Received for publication Feb 6, 1974; accepted June 6.

Reprint requests to Department of Pharmacy, Memorial Hospital Medical Center, 2801 Atlantic Ave, Long Beach, CA 90801 (Mr. Briggs).


Am J Dis Child. 1975;129(2):249-250. doi:10.1001/archpedi.1975.02120390075017.
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References
Comments

A woman with idiopathic narcolepsy of long duration was treated with large doses of dextroamphetamine sulfate throughout pregnancy. A normal girl was delivered without signs of amphetamine intoxication; she is alive and well at 18 months of age. No toxic effects or malformations have been observed in the infant. A brief discussion of the literature pertaining to amphetamine teratogenesis is presented.

REFERENCES

1 +
Zarcone V:  Narcolepsy . N Engl J Med 288:1156-1166, 1973;.
2 +
Pomerance J:  Weight gain in pregnancy: How much is enough? Clin Pediatr 11:554-556, 1972;.
3 +
Innes I, Nickerson M:  Drugs acting on post-ganglionic adrenergic nerve endings and structures innervated by them (sympathomimetic drugs) , in Goodman L, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Co, 1970;, pp 504-505.
4 +
Nora JJ, Trasler DG, Frazer FC:  Malformations in mice induced by dextroamphetamine sulphate . Lancet 2:1021-1022, 1965;.
5 +
Nora JJ, McNamara DG, Frazer FC:  Dextroamphetamine sulphate and human malformations . Lancet 1:570-571, 1967;.
6 +
Nora JJ, Vargo T, Nora A, et al:  Dextroamphetamine: A possible environmental trigger in cardiovascular malformations . Lancet 1:1290-1291, 1970;.
7 +
Gilbert E, Khoury G:  Dextroamphetamine and congenital cardiac malformations . J Pediatr 76:638, 1970;.
8 +
McIntire MS:  Possible adverse drug reaction . JAMA 197:62-63, 1966;.
9 +
Nelson M, Forfar J:  Associations between drugs administered during pregnancy and congenital abnormalities of the fetus . Br Med J 1:523-527, 1971;.
10 +
Matera R, Zabala H, Jimenez A:  Bifid exencephalia: Teratogen action of amphetamines . Int Surg 50:79-85, 1968;.
11 +
Levin J:  Amphetamine ingestion with biliary atresia . J Pediatr 79:130-131, 1971;.
12 +
Rowland M:  Amphetamine blood and urine levels in man . J Pharm Sci 58:508-509, 1969;.
13 +
Moya F, Thorndike V:  Passage of drugs across the placenta . Am J Obstet Gynecol 84:1778-1798, 1962;.
14 +
Ginsburg J:  Placental drug transfer . Annu Rev Pharmacol 2:387-408, 1971;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Zarcone V:  Narcolepsy . N Engl J Med 288:1156-1166, 1973;.
2 +
Pomerance J:  Weight gain in pregnancy: How much is enough? Clin Pediatr 11:554-556, 1972;.
3 +
Innes I, Nickerson M:  Drugs acting on post-ganglionic adrenergic nerve endings and structures innervated by them (sympathomimetic drugs) , in Goodman L, Gilman A (eds): The Pharmacological Basis of Therapeutics , ed 4. New York, Macmillan Co, 1970;, pp 504-505.
4 +
Nora JJ, Trasler DG, Frazer FC:  Malformations in mice induced by dextroamphetamine sulphate . Lancet 2:1021-1022, 1965;.
5 +
Nora JJ, McNamara DG, Frazer FC:  Dextroamphetamine sulphate and human malformations . Lancet 1:570-571, 1967;.
6 +
Nora JJ, Vargo T, Nora A, et al:  Dextroamphetamine: A possible environmental trigger in cardiovascular malformations . Lancet 1:1290-1291, 1970;.
7 +
Gilbert E, Khoury G:  Dextroamphetamine and congenital cardiac malformations . J Pediatr 76:638, 1970;.
8 +
McIntire MS:  Possible adverse drug reaction . JAMA 197:62-63, 1966;.
9 +
Nelson M, Forfar J:  Associations between drugs administered during pregnancy and congenital abnormalities of the fetus . Br Med J 1:523-527, 1971;.
10 +
Matera R, Zabala H, Jimenez A:  Bifid exencephalia: Teratogen action of amphetamines . Int Surg 50:79-85, 1968;.
11 +
Levin J:  Amphetamine ingestion with biliary atresia . J Pediatr 79:130-131, 1971;.
12 +
Rowland M:  Amphetamine blood and urine levels in man . J Pharm Sci 58:508-509, 1969;.
13 +
Moya F, Thorndike V:  Passage of drugs across the placenta . Am J Obstet Gynecol 84:1778-1798, 1962;.
14 +
Ginsburg J:  Placental drug transfer . Annu Rev Pharmacol 2:387-408, 1971;.

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