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February 1975, Vol 129, No. 2 >
Article | February 1975

Dietary Supplement and Nutrition in Children With Cystic Fibrosis FREE

Helen K. Berry, MA; Frank W. Kellogg, MD; Melanie M. Hunt, MEd; Robert L. Ingberg, MD; Lisa Richter, RN; Corrine Gutjahr, RN
[+] Author Affiliations

Received for publication March 29, 1974; accepted July 23.

Reprint requests to Department of Pediatrics, Children's Hospital Medical Center, Elland and Bethesda avenues, Cincinnati, OH 45229 (Ms. Berry).


Am J Dis Child. 1975;129(2):165-171. doi:10.1001/archpedi.1975.02120390009003.
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References
Comments

Assessment of nutritional status of patients with cystic fibrosis of the pancreas (CFP) showed that poor growth was associated with low concentrations of albumin, urea nitrogen, and cholesterol in serum and with elevated white blood cell (WBC) counts. Patients with CFP maintained weight approximately 1 standard deviation below the mean until age 8 years, after which there was a progressive decline in growth rate compared to normal. A complete dietary supplement consisting of a beef serum hydrolysate, a glucose polymer, and medium-chain triglycerides was given to 15 patients for a year. Patients who received the diet showed significant gains in weight, significant increase in clinical score, significant increase in serum albumin level, and a significant drop in the WBC count compared to control patients who did not receive the supplement.

REFERENCES

1 +
Weihofen DM, Pringle DJ:  Dietary intake and food tolerances of children with cystic fibrosis . J Am Diet Assoc 54:206-209, 1969;.
2 +
Shohl AT, May CD, Shwachman H:  Studies of nitrogen and fat metabolism on infants and children with pancreatic fibrosis . J Pediatr 23:267-279, 1943;.
3 +
West CD, Wilson JL, Eyles R:  Blood amino nitrogen levels: Changes in blood amino nitrogen levels following ingestion of proteins and of a protein hydrolysate in infants with normal and with deficient pancreatic function . Am J Dis Child 72:251-273, 1946;.
4 +
Gracey M, Burke V, Anderson CM:  Assessment of medium chain triglyceride feeding in infants with cystic fibrosis . Arch Dis Child 44:401-403, 1969;.
5 +
Allan JD, Milner J, Moss D:  Therapeutic use of an artificial diet . Lancet 1:785, 1970;.
6 +
Allan JD, Mason A, Moss AD:  Nutritional supplementation in treatment of cystic fibrosis of the pancreas . Am J Dis Child 126:22-26, 1973;.
7 +
Kumar V, Chase HP, Hammond K, et al:  Alterations in blood biochemical tests in progressive malnutrition . Pediatrics 49:736-743, 1972;.
8 +
Rananathan MK:  Biochemical changes in serum in nutritional edema . Indian J Med Res 43:517, 1955;.
9 +
McFarlane H, Alcock KJ, Cooke A, et al:  Biochemical assessment of protein-calorie malnutrition . Lancet 1:392-394, 1969;.
10 +
Simmons WK:  The plasma amino acid ratio as an indicator of the protein nutrition status: A review of recent work . Bull WHO 42:480-484, 1970;.
11 +
National Research Council, Food and Nutrition Board: Recommended Dietary Allowances: A Report , ed 7. Washington, DC, National Academy of Sciences, 1968;.
12 +
Sontag LW, Reynolds EL:  The Fels composite sheet: I. A practical method for analyzing growth progress . J Pediatr 26:327-335, 1945;.
13 +
Schwachman H, Kulczycki LL:  Long-term study of 105 patients with cystic fibrosis: Studies made over a 5- to 14-year period . Am J Dis Child 96:6-15, 1958;.
14 +
Doershuk CF, Matthews LW, Tucker AS, et al:  A 5-year clinical evaluation of a therapeutic program for patients with cystic fibrosis . J Pediatr 65:677-693, 1964;.
15 +
Arroyave G:  Comparative sensitivity of specific amino acid ratios versus "essential to non-essential" amino acid ratios . Am J Clin Nutr 23:703-706, 1970;.
16 +
Greulich WW, Pyle SI: The Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959;.
17 +
Sproul A, Huang N:  Growth patterns in children with cystic fibrosis . J Pediatr 65:664-676, 1964;.
18 +
Pollack JD, Lubin AH, Owen GM, et al: Measurement of serum total lipids in children with cystic fibrosis, abstracted. Cystic Fibrosis Club, 13th Annual Meeting, 1972, p 46.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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References

1 +
Weihofen DM, Pringle DJ:  Dietary intake and food tolerances of children with cystic fibrosis . J Am Diet Assoc 54:206-209, 1969;.
2 +
Shohl AT, May CD, Shwachman H:  Studies of nitrogen and fat metabolism on infants and children with pancreatic fibrosis . J Pediatr 23:267-279, 1943;.
3 +
West CD, Wilson JL, Eyles R:  Blood amino nitrogen levels: Changes in blood amino nitrogen levels following ingestion of proteins and of a protein hydrolysate in infants with normal and with deficient pancreatic function . Am J Dis Child 72:251-273, 1946;.
4 +
Gracey M, Burke V, Anderson CM:  Assessment of medium chain triglyceride feeding in infants with cystic fibrosis . Arch Dis Child 44:401-403, 1969;.
5 +
Allan JD, Milner J, Moss D:  Therapeutic use of an artificial diet . Lancet 1:785, 1970;.
6 +
Allan JD, Mason A, Moss AD:  Nutritional supplementation in treatment of cystic fibrosis of the pancreas . Am J Dis Child 126:22-26, 1973;.
7 +
Kumar V, Chase HP, Hammond K, et al:  Alterations in blood biochemical tests in progressive malnutrition . Pediatrics 49:736-743, 1972;.
8 +
Rananathan MK:  Biochemical changes in serum in nutritional edema . Indian J Med Res 43:517, 1955;.
9 +
McFarlane H, Alcock KJ, Cooke A, et al:  Biochemical assessment of protein-calorie malnutrition . Lancet 1:392-394, 1969;.
10 +
Simmons WK:  The plasma amino acid ratio as an indicator of the protein nutrition status: A review of recent work . Bull WHO 42:480-484, 1970;.
11 +
National Research Council, Food and Nutrition Board: Recommended Dietary Allowances: A Report , ed 7. Washington, DC, National Academy of Sciences, 1968;.
12 +
Sontag LW, Reynolds EL:  The Fels composite sheet: I. A practical method for analyzing growth progress . J Pediatr 26:327-335, 1945;.
13 +
Schwachman H, Kulczycki LL:  Long-term study of 105 patients with cystic fibrosis: Studies made over a 5- to 14-year period . Am J Dis Child 96:6-15, 1958;.
14 +
Doershuk CF, Matthews LW, Tucker AS, et al:  A 5-year clinical evaluation of a therapeutic program for patients with cystic fibrosis . J Pediatr 65:677-693, 1964;.
15 +
Arroyave G:  Comparative sensitivity of specific amino acid ratios versus "essential to non-essential" amino acid ratios . Am J Clin Nutr 23:703-706, 1970;.
16 +
Greulich WW, Pyle SI: The Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959;.
17 +
Sproul A, Huang N:  Growth patterns in children with cystic fibrosis . J Pediatr 65:664-676, 1964;.
18 +
Pollack JD, Lubin AH, Owen GM, et al: Measurement of serum total lipids in children with cystic fibrosis, abstracted. Cystic Fibrosis Club, 13th Annual Meeting, 1972, p 46.

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