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January 1975, Vol 129, No. 1 >
Article | January 1975

Systemic Lupus Erythematosus in a 1-Year-Old Child FREE

Jay Grossman, MD; Robert H. Schwartz, MD; Mary Lou Callerame, MD; John J. Condemi, MD
[+] Author Affiliations

Received for publication Jan 14, 1974; accepted June 5.

Reprint requests to 260 Crittenden Blvd, Rochester, NY 14642 (Dr. Schwartz).


Am J Dis Child. 1975;129(1):123-125. doi:10.1001/archpedi.1975.02120380093022.
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Comments

An 11-month-old girl had systemic lupus erythematosus with a widespread skin rash. She manifested five of the criteria necessary for the diagnosis: oral ulcerations, alopecia, positive lupus erythematosus preparations, convulsions, and thrombocytopenia with leukopenia. Direct immunofluorescence showed deposits of IgG and C3 at the dermoepidermal junction of both abnormal and clinically uninvolved skin, and in subepithelial deposits along the glomerular basement membrane.

REFERENCES

1 +
Dubois EL, Tuffanelli DL:  Clinical manifestations of systemic lupus erythematosus: Computer analysis of 520 cases . JAMA 190:104-111, 1964;.
2 +
Hanson V, Kornreich H:  Systemic rheumatic disorders ("collagen disease") in childhood: Lupus erythematosus, anaphylactoid purpura, dermatomyositis, and scleroderma . Bull Rheum Dis 17:435-445, 1967;.
3 +
Dubois EL: Lupus Erythematosus . New York, McGraw-Hill Book Co Inc, 1966;, p 139.
4 +
Cohen AS, Reynolds WE, Franklin EC, et al:  Preliminary criteria for the classification of systemic lupus erythematosus . Bull Rheum Dis 21:643-648, 1971;.
5 +
Kay DM, Tuffanelli DL:  Immunofluorescent techniques in clinical diagnosis of cutaneous disease . Ann Intern Med 71:753-762, 1969;.
6 +
Percy JS, Smyth CJ:  The immunofluorescent skin test in systemic lupus erythematosus . JAMA 208:485-488, 1969;.
7 +
Lever WF:  Pemphigoid , in Fitzpatrick TB (ed): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1971;, p 609.
8 +
Condemi JJ, Grossman J, Callerame ML:  Immunofluorescent studies on skin biopsies from patients with systemic lupus erythematosus and other antinuclear antibody positive diseases . Arthritis Rheum 15:433, 1972;.
9 +
Peterson RDA, Vernier RL, Good RA:  Lupus erythematosus . Pediatr Clin North Am 10:941-978, 1963;.
10 +
Tuffanelli DL, La Perriere R:  Connective tissue diseases . Pediatr Clin North Am 18:925-951, 1971;.
11 +
Finegold I, Middleton E:  Positive lupus erythematosus preparations and penicillin sensitivity . J Allergy Clin Immunol 48:115-119, 1971;.
12 +
Shulman LE, Harvey AM:  Systemic lupus erythematosus , in Hollander JL, McCarty DJ (eds): Arthritis and Allied Conditions . Philadelphia, Lea & Febiger, 1972;, p 895.
13 +
Hogg GR:  Congenital acute lupus erythematosus associated with subendocardial fibroelastosis . Am J Clin Pathol 28:648-654, 1957;.
14 +
Seip M:  Systemic lupus erythematosus in pregnancy with hemolytic anaemia, leucopenia and thrombocytopenia in the mother and her newborn infant . Arch Dis Child 35:364-366, 1960;.
15 +
Bridge RG, Foley FE:  Placental transmission of the lupus erythematosus factor . Am J Med Sci 227:1-8, 1954;.
16 +
Nice CM:  Congenital disseminated lupus erythematosus . Am J Roentgenol Radium Ther Nucl Med 88:585-587, 1962;.
17 +
Ahmadian YS, Given GZ, Mendoza SA:  Normal urine and positive immunofluorescence reaction in lupus nephritis . Am J Dis Child 123:121-125, 1972;.

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References

1 +
Dubois EL, Tuffanelli DL:  Clinical manifestations of systemic lupus erythematosus: Computer analysis of 520 cases . JAMA 190:104-111, 1964;.
2 +
Hanson V, Kornreich H:  Systemic rheumatic disorders ("collagen disease") in childhood: Lupus erythematosus, anaphylactoid purpura, dermatomyositis, and scleroderma . Bull Rheum Dis 17:435-445, 1967;.
3 +
Dubois EL: Lupus Erythematosus . New York, McGraw-Hill Book Co Inc, 1966;, p 139.
4 +
Cohen AS, Reynolds WE, Franklin EC, et al:  Preliminary criteria for the classification of systemic lupus erythematosus . Bull Rheum Dis 21:643-648, 1971;.
5 +
Kay DM, Tuffanelli DL:  Immunofluorescent techniques in clinical diagnosis of cutaneous disease . Ann Intern Med 71:753-762, 1969;.
6 +
Percy JS, Smyth CJ:  The immunofluorescent skin test in systemic lupus erythematosus . JAMA 208:485-488, 1969;.
7 +
Lever WF:  Pemphigoid , in Fitzpatrick TB (ed): Dermatology in General Medicine . New York, McGraw-Hill Book Co Inc, 1971;, p 609.
8 +
Condemi JJ, Grossman J, Callerame ML:  Immunofluorescent studies on skin biopsies from patients with systemic lupus erythematosus and other antinuclear antibody positive diseases . Arthritis Rheum 15:433, 1972;.
9 +
Peterson RDA, Vernier RL, Good RA:  Lupus erythematosus . Pediatr Clin North Am 10:941-978, 1963;.
10 +
Tuffanelli DL, La Perriere R:  Connective tissue diseases . Pediatr Clin North Am 18:925-951, 1971;.
11 +
Finegold I, Middleton E:  Positive lupus erythematosus preparations and penicillin sensitivity . J Allergy Clin Immunol 48:115-119, 1971;.
12 +
Shulman LE, Harvey AM:  Systemic lupus erythematosus , in Hollander JL, McCarty DJ (eds): Arthritis and Allied Conditions . Philadelphia, Lea & Febiger, 1972;, p 895.
13 +
Hogg GR:  Congenital acute lupus erythematosus associated with subendocardial fibroelastosis . Am J Clin Pathol 28:648-654, 1957;.
14 +
Seip M:  Systemic lupus erythematosus in pregnancy with hemolytic anaemia, leucopenia and thrombocytopenia in the mother and her newborn infant . Arch Dis Child 35:364-366, 1960;.
15 +
Bridge RG, Foley FE:  Placental transmission of the lupus erythematosus factor . Am J Med Sci 227:1-8, 1954;.
16 +
Nice CM:  Congenital disseminated lupus erythematosus . Am J Roentgenol Radium Ther Nucl Med 88:585-587, 1962;.
17 +
Ahmadian YS, Given GZ, Mendoza SA:  Normal urine and positive immunofluorescence reaction in lupus nephritis . Am J Dis Child 123:121-125, 1972;.

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