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Article |

Multilamellar Cytosomes in a Particular Form of Late-Infantile Amaurotic Idiocy

Jacob C. Jacob, FRCP(C); Geoffrey Rowden, PhD; Madhavan Kutty, PhD; Moinuddin Islam, MRC Path
Am J Dis Child. 1975;129(1):109-112. doi:10.1001/archpedi.1975.02120380079018.
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There is a particular form of late-infantile amaurotic idiocy in which no clear chemical-pathological or unique enzyme abnormalities have been identified to date. A distinctive morphological feature has been recognized on electron microscopical examination of tissues from these patients, which has been descriptively labeled with various terms, including "multilamellar cytosomes" (MLC).

Illustrations of MLC in a patient with this late-infantile form of cerebroretinal degeneration show their reactivity with the periodic acid-silver methenamine reaction for glycoproteins. The MLC are shown to be morphologically identical in cerebral tissue obtained at biopsy, in the same tissue obtained three years later at autopsy, and in skeletal muscle.


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