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December 1974, Vol 128, No. 6 >
Article | December 1974

Malignant Mesenchymoma in Infants FREE

Catherine M. Holdsworth Mayer, MB, BS; Blaise E. Favara, MD; Charlene P. Holton, MD; W. Gerald Rainer, MD, MS
[+] Author Affiliations

Received for publication Nov 19, 1973; accepted April 23, 1974.

Reprint requests to Oncology Center, the Children's Hospital, 1056 E 19th Ave, Denver, CO 80218 (Dr. Mayer).


Am J Dis Child. 1974;128(6):847-850. doi:10.1001/archpedi.1974.02110310095019.
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References
Comments

Two infants with malignant mesenchymoma had favorable responses to surgery and chemotherapy. The cases of 19 other infants with this neoplasm are reviewed, stressing diagnostic criteria and the role of chemotherapy in management.

REFERENCES

1 +
Kipkie GF, Haust MD:  Malignant mesenchymoma (haemangioblastomyxomatous variety) in a 5-year-old boy . Can Med Assoc J 81:179-182, 1959;.
2 +
Nuessle RF:  Mesodermal mixed tumors . Lancet 85:275-278, 1965;.
3 +
Ross CF, Hadfield G:  Primary osteo-liposarcoma of bone (malignant mesenchymoma): Report of a case . J Bone Joint Surg [Br] 50:639-643, 1968;.
4 +
Schajowicz F, Cuevillas AR, Silberman FS:  Primary malignant mesenchymoma of bone: A new tumor entity . Cancer 19:1423-1428, 1966;.
5 +
Small GS:  Malignant mesenchymoma of the mandible . Oral Surg 14:1427-1435, 1961;.
6 +
Sterns EE, Haust MD, Wollin DG:  Malignant mesenchymoma of the mandible . Can J Surg 12:444-449, 1969;.
7 +
Symmers WSC, Nangle EJ:  An unusual recurring tumor formed of connective tissues of embryonic type (so-called mesenchymoma) . J Pathol Bacteriol 63:419-428, 1951;.
8 +
Hyde WR, White JE, Stout AP:  Mesenchymoma of the mesentery . Cancer 3:653-656, 1950;.
9 +
Stout AP:  Sarcomas of soft parts . J Missouri Med Assoc 44:329-334, 1947;.
10 +
Stout AP:  Mesenchymoma, the mixed tumor of mesenchymal derivatives . Ann Surg 127:278-290, 1948;.
11 +
Stout AP:  Tumors of the soft tissues , in Atlas of Tumor Pathology . Washington, DC, Armed Forces Institute of Pathology, 1953;, sec 11, fascicle 5, pp 118-119.
12 +
Stout AP, Lattes R:  Tumors of the soft tissues , in Atlas of Tumor Pathology . Washington, DC, Armed Forces Institute of Pathology, 1967;, series 2, fascicle 1, pp 172-173.
13 +
Alston EF, Paulson DL:  Mesenchymoma of pleura: Case report . J Thoracic Surg 18:518-525, 1949;.
14 +
Gaynor WB, DeLashmutt RE:  Malignant mesenchymoma arising in the scar of a thermal burn . Am J Clin Pathol 28:74-81, 1957;.
15 +
Munk J, et al:  Primary mesenchymoma of the pulmonary artery: Radiological features . Br J Radiol 38:104-111, 1965;.
16 +
Pack GT, Lisa JR:  Mesenchymoma: Report of a case . Surgery 35:277-282, 1954;.
17 +
Pemberton M, Cromack PL:  Mesenchymoma (angioliposarcoma) of the thigh . J Bone Joint Surg [Br] 35:584-588, 1953;.
18 +
Anderson DH:  Tumors of infancy and childhood: I. A survey of those seen in the pathology laboratory of the Babies Hospital during the years 1935-1950 . Cancer 4:890-906, 1951;.
19 +
Donovan EJ, Santulli TV:  Resection of the left lobe of the liver for mesenchymoma: Report of a case . Ann Surg 124:90-93, 1946;.
20 +
Nash A, Stout AP:  Malignant mesenchymomas in children . Cancer 14:524-533, 1961;.
21 +
Pachter MR, Lattes R:  Mesenchymal tumors of the mediastinum . Cancer 16:74-94, 1963;.
22 +
Soule EH, et al:  Soft tissue sarcomas of infants and children . Mayo Clin Proc 43:313-326, 1968;.
23 +
Wilson FC Jr, Parkes JC:  Mixed mesodermal tumor (mesenchymoma) of the extremities . Clin Orthop 41:133-139, 1965;.
24 +
Darling DB, Segi K, MacMahon HE:  Malignant mesenchymoma of pleura in infancy: Report of a case . JAMA 199:848-849, 1967;.
25 +
Kauffman SL, Stout AP:  Congenital mesenchymal tumors . Cancer 18:460-476, 1965;.
26 +
Kumar R, Saifullah S:  Mesenchymoma in a newborn: Report of a case . Indian J Pediatr 35:144-145, 1968;.
27 +
Smith AM, Becker JA:  Malignant mesenchymomas of the retroperitoneum . Am J Roentgenol Radium Ther Nucl Med 104:389-393, 1968;.
28 +
Touloukian RJ, De Luca FG:  Unique aspects of small-intestinal intussusception in infants and children: Intussusceptions due to a metastatic malignant mesenchymoma and an indwelling long intestinal tube . Surgery 63:346-351, 1968;.
29 +
Pratt CB:  Response of childhood rhabdomyosarcoma to combination chemotherapy . J Pediatr 74:791-794, 1969;.
30 +
Pratt CB, et al:  Combination therapy including vincristine for malignant solid tumors in children . Cancer Chemother Rep 52:489-495, 1968;.
31 +
Holton CP, et al:  Extended combination therapy of childhood rhabdomyosarcoma . Cancer 6:1310-1316, 1973;.
32 +
Klein W:  Mesenchymoma . J Med Soc NJ 29:774, 1932;.
33 +
McFarland J:  Dysontogenetic and mixed tumors of the urogenital region . Surg Gynecol Obstet 61:42-57, 1935;.
34 +
Marburg O:  Meningeal tumor following foreign body: (meningeal mesenchymoma) . Virchows Arch [Pathol Anat] 294:759, 1934-1935;.
35 +
Tauber EB, Goldman L, Barrett C:  Mesenchymoma: A new type of turban tumor . Arch Derm Syph 37:444-450, 1938;.
36 +
Takacs F:  Peculiar tumor originating in the uterus (mesenchymoma embryonale angioplasticum) . Virchows Arch [Pathol Anat] 309:550-560, 1942;.
37 +
Novak E: Gynecological and Obstetrical Pathology , ed 6. Philadelphia, WB Saunders Co, 1967;, p 400.
38 +
Gilmour JR:  A recurrent tumor of mesenchyme in an adult . J Pathol Bacteriol 55:495-499, 1943;.
39 +
Cabanne F, et al:  The mesenchymomas: Attempted anatomic-clinical restatement . Ann Anat Pathol 13:21-42, 1968;.
40 +
Pack GT, Ariel IM: Treatment of Cancer and Allied Diseases , ed 2. New York, Paul B Hoeber Inc, 1963;, vol 8, p 17.
41 +
Stout AP:  Recent observations of mesenchymal tumors in adults and children . Can Med Assoc J 88:453-456, 1963;.
42 +
Stout AP:  Pathological aspects of soft part sarcomas . Ann NY Acad Sci 114:1041-1046, 1964;.
43 +
Willis RA: The Pathology of Tumors of Children: Pathological Monographs No. 2 . Springfield, Ill, Charles C Thomas Publisher, 1962;, p 148.
44 +
Lawrence EA, Donlan EJ:  Neoplastic diseases in infants and children . Cancer Res 12:900-904, 1952;.
45 +
Wells HG:  Occurrence and significance of congenital malignant neoplasms . Arch Pathol 30:535-601, 1940;.
46 +
Pratt CB, et al:  Coordinated treatment of childhood rhabdomyosarcoma with surgery, radiotherapy and combination chemotherapy . Cancer Res 32:606-610, 1972;.

Figures

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Interactive Graphics

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Kipkie GF, Haust MD:  Malignant mesenchymoma (haemangioblastomyxomatous variety) in a 5-year-old boy . Can Med Assoc J 81:179-182, 1959;.
2 +
Nuessle RF:  Mesodermal mixed tumors . Lancet 85:275-278, 1965;.
3 +
Ross CF, Hadfield G:  Primary osteo-liposarcoma of bone (malignant mesenchymoma): Report of a case . J Bone Joint Surg [Br] 50:639-643, 1968;.
4 +
Schajowicz F, Cuevillas AR, Silberman FS:  Primary malignant mesenchymoma of bone: A new tumor entity . Cancer 19:1423-1428, 1966;.
5 +
Small GS:  Malignant mesenchymoma of the mandible . Oral Surg 14:1427-1435, 1961;.
6 +
Sterns EE, Haust MD, Wollin DG:  Malignant mesenchymoma of the mandible . Can J Surg 12:444-449, 1969;.
7 +
Symmers WSC, Nangle EJ:  An unusual recurring tumor formed of connective tissues of embryonic type (so-called mesenchymoma) . J Pathol Bacteriol 63:419-428, 1951;.
8 +
Hyde WR, White JE, Stout AP:  Mesenchymoma of the mesentery . Cancer 3:653-656, 1950;.
9 +
Stout AP:  Sarcomas of soft parts . J Missouri Med Assoc 44:329-334, 1947;.
10 +
Stout AP:  Mesenchymoma, the mixed tumor of mesenchymal derivatives . Ann Surg 127:278-290, 1948;.
11 +
Stout AP:  Tumors of the soft tissues , in Atlas of Tumor Pathology . Washington, DC, Armed Forces Institute of Pathology, 1953;, sec 11, fascicle 5, pp 118-119.
12 +
Stout AP, Lattes R:  Tumors of the soft tissues , in Atlas of Tumor Pathology . Washington, DC, Armed Forces Institute of Pathology, 1967;, series 2, fascicle 1, pp 172-173.
13 +
Alston EF, Paulson DL:  Mesenchymoma of pleura: Case report . J Thoracic Surg 18:518-525, 1949;.
14 +
Gaynor WB, DeLashmutt RE:  Malignant mesenchymoma arising in the scar of a thermal burn . Am J Clin Pathol 28:74-81, 1957;.
15 +
Munk J, et al:  Primary mesenchymoma of the pulmonary artery: Radiological features . Br J Radiol 38:104-111, 1965;.
16 +
Pack GT, Lisa JR:  Mesenchymoma: Report of a case . Surgery 35:277-282, 1954;.
17 +
Pemberton M, Cromack PL:  Mesenchymoma (angioliposarcoma) of the thigh . J Bone Joint Surg [Br] 35:584-588, 1953;.
18 +
Anderson DH:  Tumors of infancy and childhood: I. A survey of those seen in the pathology laboratory of the Babies Hospital during the years 1935-1950 . Cancer 4:890-906, 1951;.
19 +
Donovan EJ, Santulli TV:  Resection of the left lobe of the liver for mesenchymoma: Report of a case . Ann Surg 124:90-93, 1946;.
20 +
Nash A, Stout AP:  Malignant mesenchymomas in children . Cancer 14:524-533, 1961;.
21 +
Pachter MR, Lattes R:  Mesenchymal tumors of the mediastinum . Cancer 16:74-94, 1963;.
22 +
Soule EH, et al:  Soft tissue sarcomas of infants and children . Mayo Clin Proc 43:313-326, 1968;.
23 +
Wilson FC Jr, Parkes JC:  Mixed mesodermal tumor (mesenchymoma) of the extremities . Clin Orthop 41:133-139, 1965;.
24 +
Darling DB, Segi K, MacMahon HE:  Malignant mesenchymoma of pleura in infancy: Report of a case . JAMA 199:848-849, 1967;.
25 +
Kauffman SL, Stout AP:  Congenital mesenchymal tumors . Cancer 18:460-476, 1965;.
26 +
Kumar R, Saifullah S:  Mesenchymoma in a newborn: Report of a case . Indian J Pediatr 35:144-145, 1968;.
27 +
Smith AM, Becker JA:  Malignant mesenchymomas of the retroperitoneum . Am J Roentgenol Radium Ther Nucl Med 104:389-393, 1968;.
28 +
Touloukian RJ, De Luca FG:  Unique aspects of small-intestinal intussusception in infants and children: Intussusceptions due to a metastatic malignant mesenchymoma and an indwelling long intestinal tube . Surgery 63:346-351, 1968;.
29 +
Pratt CB:  Response of childhood rhabdomyosarcoma to combination chemotherapy . J Pediatr 74:791-794, 1969;.
30 +
Pratt CB, et al:  Combination therapy including vincristine for malignant solid tumors in children . Cancer Chemother Rep 52:489-495, 1968;.
31 +
Holton CP, et al:  Extended combination therapy of childhood rhabdomyosarcoma . Cancer 6:1310-1316, 1973;.
32 +
Klein W:  Mesenchymoma . J Med Soc NJ 29:774, 1932;.
33 +
McFarland J:  Dysontogenetic and mixed tumors of the urogenital region . Surg Gynecol Obstet 61:42-57, 1935;.
34 +
Marburg O:  Meningeal tumor following foreign body: (meningeal mesenchymoma) . Virchows Arch [Pathol Anat] 294:759, 1934-1935;.
35 +
Tauber EB, Goldman L, Barrett C:  Mesenchymoma: A new type of turban tumor . Arch Derm Syph 37:444-450, 1938;.
36 +
Takacs F:  Peculiar tumor originating in the uterus (mesenchymoma embryonale angioplasticum) . Virchows Arch [Pathol Anat] 309:550-560, 1942;.
37 +
Novak E: Gynecological and Obstetrical Pathology , ed 6. Philadelphia, WB Saunders Co, 1967;, p 400.
38 +
Gilmour JR:  A recurrent tumor of mesenchyme in an adult . J Pathol Bacteriol 55:495-499, 1943;.
39 +
Cabanne F, et al:  The mesenchymomas: Attempted anatomic-clinical restatement . Ann Anat Pathol 13:21-42, 1968;.
40 +
Pack GT, Ariel IM: Treatment of Cancer and Allied Diseases , ed 2. New York, Paul B Hoeber Inc, 1963;, vol 8, p 17.
41 +
Stout AP:  Recent observations of mesenchymal tumors in adults and children . Can Med Assoc J 88:453-456, 1963;.
42 +
Stout AP:  Pathological aspects of soft part sarcomas . Ann NY Acad Sci 114:1041-1046, 1964;.
43 +
Willis RA: The Pathology of Tumors of Children: Pathological Monographs No. 2 . Springfield, Ill, Charles C Thomas Publisher, 1962;, p 148.
44 +
Lawrence EA, Donlan EJ:  Neoplastic diseases in infants and children . Cancer Res 12:900-904, 1952;.
45 +
Wells HG:  Occurrence and significance of congenital malignant neoplasms . Arch Pathol 30:535-601, 1940;.
46 +
Pratt CB, et al:  Coordinated treatment of childhood rhabdomyosarcoma with surgery, radiotherapy and combination chemotherapy . Cancer Res 32:606-610, 1972;.

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