Rubella Virus Immunization of Preschool Children via the Respiratory Tract FREE

Rama Ganguly, PhD; Brigitte Durrer; Robert H. Waldman, MD

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Received for publication Feb 25, 1974; accepted June 16.

Reprint requests to PO Box 732, J. Hillis Miller Health Center, Gainesville, FL 32610 (Dr. Waldman).

Am J Dis Child. 1974;128(6):821-823. doi:10.1001/archpedi.1974.02110310069012.

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ABSTRACT

ABSTRACT | REFERENCES

The efficacy of various routes of administration of rubella vaccine RA27/3 was evaluated in a group of children. The vaccinees were randomly divided into three groups: subcutaneous, nose drop, and aerosol spray. Immunization was evaluated in terms of serum antibody rise and clinical side effects.

Seroconversion was achieved in 100% of the children with no significant difference in the geometric mean titers of serum antibody in the various groups. Thus, respiratory tract immunization of small children with rubella vaccine RA27/3 is equally effective, compared to the subcutaneous route, in stimulating serum antibody. Side effects occurred in only 4% of the vaccinees in each group, the symptoms being mild and transient. We believe local immunization is less painful than subcutaneous injection and is an acceptable technique for mass administration of the vaccine in children.

REFERENCES

ABSTRACT | REFERENCES

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Plotkin SA, Farquhar JD, Katz M, et al: Attenuation of RA27/3 rubella virus in WI-38 human diploid cells . Am J Dis Child 118:178-185, 1969;.

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Ingalls TH, Plotkin SA, Philbrook FR, et al: Immunization of school children with rubella (RA27-3) vaccine . Lancet 1:99-101, 1970;.
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Ogra PL, Kerr-Grant D, Umana G, et al: Antibody response in serum and nasopharynx after naturally acquired and vaccine induced infection with rubella virus . N Engl J Med 285:1333-1339, 1971;.
Link to Article

Naficy K, Nategh R, Ahangary S, et al: Artificial challenge studies in rubella: Utilization of RA27/3 rubella vaccinees, rubella naturally acquired seropositives, and rubella susceptible children . Am J Dis Child 120:520-523, 1970;.

Liebhaber H, Ingalls TH, Le Bouvier GL, et al: Vaccination with RA27/3 rubella vaccine: Persistence of immunity and resistance to challenge after two years . Am J Dis Child 123:133-136, 1972;.

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Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal