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October 1974, Vol 128, No. 4 >
Article | October 1974

CLINICAL MEMORANDUM Lead Content of Aspirin FREE

JOHN D. BOGDEN, PHD; NARAYANI P. SINGH, PHD
Am J Dis Child. 1974;128(4):582. doi:10.1001/archpedi.1974.02110290152026.
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Excessive and dangerous lead contents have recently been found in a number of unexpected sources, including colored printing inks1 and toothpaste.2 The pervasiveness of lead contamination suggested an examination of the lead content of aspirin. Aspirin was chosen because of its high rate of consumption in the United States, because of its ready availability as a nonprescription drug, and because of the possibilities for lead contamination during its manufacture. Dust in the manufacturing plants or corrosion of pipes and vessels with the sulfuric or acetic acids used could result in lead contamination of aspirin.

Surprisingly, the United States Pharmacopeia specifies that aspirin may contain as much as 10 ppm of lead.3 This represents a daily intake of 50μg of lead if ten ½-gm tablets are taken daily. This would be a substantial amount of ingested lead, especially when added to the 200μg to 300μg ingested daily from

REFERENCES

1 +
Joselow MM, Bogden JD:  Lead content of printed media . Am J Public Health 64:238-240, 1974;.
Link to Article
2 +
Berman E, McKiel K:  Is that toothpaste safe? Arch Environ Health 25:64-65, 1972;.
Link to Article
3 +
The Pharmacopeia of the United States of America: (The United States Pharmacopeia) . Bethesda, Md, The United States Pharmacopeial Convention Inc, 1970;.
4 +
Browder AA, Joselow MM, Louria DB:  The problem of lead poisoning . Medicine 52:121-139, 1973;.
Link to Article
5 +
King BG:  Maximum daily intake of lead without excessive body lead-burden in children . Am J Dis Child 122:337-340, 1971;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

1 +
Joselow MM, Bogden JD:  Lead content of printed media . Am J Public Health 64:238-240, 1974;.
Link to Article
2 +
Berman E, McKiel K:  Is that toothpaste safe? Arch Environ Health 25:64-65, 1972;.
Link to Article
3 +
The Pharmacopeia of the United States of America: (The United States Pharmacopeia) . Bethesda, Md, The United States Pharmacopeial Convention Inc, 1970;.
4 +
Browder AA, Joselow MM, Louria DB:  The problem of lead poisoning . Medicine 52:121-139, 1973;.
Link to Article
5 +
King BG:  Maximum daily intake of lead without excessive body lead-burden in children . Am J Dis Child 122:337-340, 1971;.

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