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Article |

Pharmacological Basis for Antimicrobial Therapy in Newborn Infants

George H. McCracken Jr., MD
Am J Dis Child. 1974;128(3):407-419. doi:10.1001/archpedi.1974.02110280137022.
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The neonate is physiologically and pharmacologically unique, a fact that is frequently overlooked when physicians prescribe antimicrobial therapy during the neonatal period. Pharmacology, clinical efficacy, and safety must be defined for every drug prior to routine use in newborn and young infants. Recommendations for dosage and frequency of administration for the six most commonly used antibiotics in neonates are reviewed. These dosage schedules are based on pharmacokinetic data and have proved to be safe and effective in the therapy of neonatal bacterial infections. All infants receiving antibiotics should be carefully examined for possible toxic effects due to these drugs.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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