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Article |

Hypoxemia and Critical Flicker Frequency in Congenital Heart Disease

Ruth B. Aisenberg, PhD; Amnon Rosenthal, MD; Peter H. Wolff, MD; Alexander S. Nadas, MD
Am J Dis Child. 1974;128(3):335-338. doi:10.1001/archpedi.1974.02110280065008.
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The relationship between the arterial oxygen saturation level and performance on a centrally mediated task was determined in patients with congenital heart disease. The critical flicker frequency (CFF) of 212 acyanotic and 66 cyanotic patients with congenital heart disease, with arterial oxygen saturation levels below 90%, was determined by a standardized technique. The CFFs of the cyanotic patients as a group were significantly lower than those of the acyanotic patients. Within the cyanotic group, the patients with the lower arterial oxygen saturation level had the lower CFFs. These data support the hypothesis that the hypoxemia associated with cyanotic congenital heart disease does impair central nervous system functioning.


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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