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Fundamental Problems of Cystic Fibrosis and Related Diseases.

Am J Dis Child. 1974;128(2):267. doi:10.1001/archpedi.1974.02110270141043.
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This book comes from a cystic fibrosis (CF) congress that summarized clinical and research knowledge of cystic fibrosis and alpha1-antitrypsin deficiency. The conference was sponsored by the National Cystic Fibrosis Research Foundation, the National Heart and Lung Institute, and the International Cystic Fibrosis (Mucoviscidosis) Foundation.

The presentations are made by leaders of the various aspects of these fields. The result is a timely and authoritative survey. In subjects that are controversial, the various data and viewpoints are covered.

In the introduction, Paul A. di Sant'Agnese, MD, ScD(Med), states that "CF is the most common lethal genetic disease of Caucasian peoples," appearing in one out of 2,000 live births, so that one in 20 of the general population are heterozygous.

Kurt Hirschhorn, MD, describes refinement of the Spock method for bioassay of the ciliary dyskinesia factor in serum and cell culture media, with use of rabbit tracheal cilia. This detects homozygotes


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