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Die Normale und Gestörte Praepuberale Hodenentwicklung des Menschen.

G. JAN BRUINING, MD
Am J Dis Child. 1974;128(2):264. doi:10.1001/archpedi.1974.02110270138038.
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ABSTRACT

This book, written in German, provides a wealth of data on the morphology of the prepubertal testes in 202 boys in a variety of defined conditions. Increasingly, specimens of testicular tissue are being offered to pathologists for diagnosis. The aim of this monograph is to determine which morphologic criteria can be used for delayed or accelerated testicular development in boys from 1 to 11 years of age. To date, the literature contains no systematic body of data on presumably normal testes on such large a scale.

Pathologic conditions are very well defined in this study. Boys who died of an acute condition and whose height and weight were between 97.5 and 2.5 percentiles are considered normal. Changes in average testis weight, tubule diameter, and number of spermatogonia were chosen as parameters. Linear progressions with age for all these parameters are shown in separate plots. After extensive statistical evaluation, values for

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