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Successful Treatment of Systemic Candidiasis Following Cardiac Surgery

Philip J. Kozinn, MD; Joshua Lynfield, MD; Mildred S. Seelig, MD, MPH
Am J Dis Child. 1974;128(1):106-108. doi:10.1001/archpedi.1974.02110260108022.
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A 28-month-old boy developed infection of the pleural cavity and cardiac failure following open-heart surgery for transposition of the great vessels. Treatment with antibiotics, digitalis, aspirin, and a course of hyperbaric oxygen did not alleviate the signs and symptoms. Candida albicans was cultured from the chest tube drainage, a pleural aspirate, the pacemaker wire, urine, and pharynx. Blood and stool cultures were negative for C albicans. There were persistently elevated Candida antibody titers. Only after therapy with clotrimazole, an orally given antifungal drug, was begun did the signs and symptoms of infection disappear and the Candida antibody levels drop to normal. The patient remains well two years postoperatively and has normal Candida antibody levels.


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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