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Pancreatic Acinar Cell Carcinoma in Childhood FREE

Puay-Tim Mah, MB, BS, MRACP; David C. Loo, MMB, BS, DCP, MRCPath; Edward P. C. Tock, MD, PhD, FCAP, FRCPA
[+] Author Affiliations

Received for publication Sept 28, 1973; accepted Dec 22.

Reprint requests to the Department of Pathology, University of Singapore, Outram Rd, Singapore 3 (Dr. Tock).


Am J Dis Child. 1974;128(1):101-104. doi:10.1001/archpedi.1974.02110260103021.
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A 9-year-old Chinese boy with abdominal pain and an abdominal mass was found at laparotomy to have carcinoma of the pancreas. Histologically, this was an acinar cell carcinoma, which is an extremely rare condition, especially in childhood. The patient survived for ten months after pancreatoduodenectomy and choledochojejunostomy. A review of the literature showed that in contrast to adults, jaundice was an uncommon finding in children with pancreatic carcinoma, and that an enlarging abdomen or an abdominal mass was the initial feature in the majority of patients. Prognosis was poor even with treatment, the longest survivor having lived for five years after pancreatoduodenectomy.

REFERENCES

Cliffton EE:  Carcinoma of the pancreas . Am J Med 21:760-780, 1956;.
Link to Article
Corner BD:  Primary carcinoma of the pancreas in an infant aged 7 months . Arch Dis Child 18:106-108, 1943;.
Link to Article
Moynan RW, Neerhout RC, Johnson TS:  Pancreatic carcinoma in childhood: Case report and review . J Pediatr 65:711-720, 1964;.
Link to Article
Feable WJ:  Carcinoma of the pancreas: Infantile type—light and electron micrscopic study . Cancer 27:667-673, 1971;.
Link to Article
Morlock CG, Dockerty MB:  Carcinoma of the pancreas during the first two decades of life: Report of two cases . Postgrad Med 26:329-333, 1959;.
Fonkalsrud EW, Wilkerson JA, Longmire WP:  Pancreatoduodenectomy for islet-cell tumor of the pancreas in infancy and childhood . JAMA 197:586-588, 1966;.
Link to Article
Grosfeld JL, Clatworthy HW Jr, Hamoudi AB:  Pancreatic malignancy in children . Arch Surg 101: 370-375, 1970;.
Link to Article
Becker WF:  Pancreatoduodenectomy for carcinoma of the pancreas in an infant: Report of a case . Ann Surg 145:864-872, 1957;.
Link to Article
Warthen RO, Sanford MC, Rice EC:  Primary malignant tumor of the pancreas in a 15-month-old boy . Am J Dis Child 83:663-666, 1952;.
Malcolm JD:  Removal of a sarcomatous tumor from the tail of the pancreas of a child 4 years and 8 months old . Lancet 1:586-588, 1902;.
Link to Article
Adams CWM:  A p-dimethylaminobenzaldehyde-nitrite method for the histochemical demonstration of tryptophane and related compounds . J Clin Pathol 10:56-62, 1957;.
Link to Article
Whipple AO, cited by Cliffton EE:  Carcinoma of the pancreas . Am J Med 21:760-780, 1956;.
Link to Article
Bouchier IAD:  Cancer of the pancreas . Br Med J 3:169-171, 1968;.
Link to Article
Belsky H, Cornell NW:  Disseminated focal fat necrosis following radical pancreatico-duodenectomy for acinous carcinoma of head of pancreas . Ann Surg 141:556-562, 1955;.
Link to Article
Auger C:  Acinous cell carcinoma of the pancreas with extensive fat necrosis . Arch Pathol 43:400-405, 1947;.
Osborne RR:  Functioning acinous cell carcinoma of the pancreas accompanied with widespread focal fat necrosis . Arch Intern Med 85:933-943, 1950;.
Link to Article
Alcantara EN Jr:  Functioning acinar cell carcinoma of the pancreas . Can Med Assoc J 87:970-973, 1962;.
Comfort MW, et al:  Acinar cell carcinoma of the pancreas: Report of a case in which function of carcinomatous cells was suspected . Ann Intern Med 19:808-816, 1943;.
Link to Article

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Cliffton EE:  Carcinoma of the pancreas . Am J Med 21:760-780, 1956;.
Link to Article
Corner BD:  Primary carcinoma of the pancreas in an infant aged 7 months . Arch Dis Child 18:106-108, 1943;.
Link to Article
Moynan RW, Neerhout RC, Johnson TS:  Pancreatic carcinoma in childhood: Case report and review . J Pediatr 65:711-720, 1964;.
Link to Article
Feable WJ:  Carcinoma of the pancreas: Infantile type—light and electron micrscopic study . Cancer 27:667-673, 1971;.
Link to Article
Morlock CG, Dockerty MB:  Carcinoma of the pancreas during the first two decades of life: Report of two cases . Postgrad Med 26:329-333, 1959;.
Fonkalsrud EW, Wilkerson JA, Longmire WP:  Pancreatoduodenectomy for islet-cell tumor of the pancreas in infancy and childhood . JAMA 197:586-588, 1966;.
Link to Article
Grosfeld JL, Clatworthy HW Jr, Hamoudi AB:  Pancreatic malignancy in children . Arch Surg 101: 370-375, 1970;.
Link to Article
Becker WF:  Pancreatoduodenectomy for carcinoma of the pancreas in an infant: Report of a case . Ann Surg 145:864-872, 1957;.
Link to Article
Warthen RO, Sanford MC, Rice EC:  Primary malignant tumor of the pancreas in a 15-month-old boy . Am J Dis Child 83:663-666, 1952;.
Malcolm JD:  Removal of a sarcomatous tumor from the tail of the pancreas of a child 4 years and 8 months old . Lancet 1:586-588, 1902;.
Link to Article
Adams CWM:  A p-dimethylaminobenzaldehyde-nitrite method for the histochemical demonstration of tryptophane and related compounds . J Clin Pathol 10:56-62, 1957;.
Link to Article
Whipple AO, cited by Cliffton EE:  Carcinoma of the pancreas . Am J Med 21:760-780, 1956;.
Link to Article
Bouchier IAD:  Cancer of the pancreas . Br Med J 3:169-171, 1968;.
Link to Article
Belsky H, Cornell NW:  Disseminated focal fat necrosis following radical pancreatico-duodenectomy for acinous carcinoma of head of pancreas . Ann Surg 141:556-562, 1955;.
Link to Article
Auger C:  Acinous cell carcinoma of the pancreas with extensive fat necrosis . Arch Pathol 43:400-405, 1947;.
Osborne RR:  Functioning acinous cell carcinoma of the pancreas accompanied with widespread focal fat necrosis . Arch Intern Med 85:933-943, 1950;.
Link to Article
Alcantara EN Jr:  Functioning acinar cell carcinoma of the pancreas . Can Med Assoc J 87:970-973, 1962;.
Comfort MW, et al:  Acinar cell carcinoma of the pancreas: Report of a case in which function of carcinomatous cells was suspected . Ann Intern Med 19:808-816, 1943;.
Link to Article

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